Linked Life Data

12051993

Source:http://linkedlifedata.com/resource/pubmed/id/12051993

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-6-7
pubmed:abstractText
Recent studies have suggested that inducible nitric oxide synthase (iNOS) plays a role in the development of asbestos-related pulmonary disorders. The pulmonary reactions of rats and hamsters upon exposure to asbestos fibers are well known to be disparate. In addition, in vitro experiments have indicated that mononuclear phagocytes from hamsters, in contrast to those from rats, lack the iNOS pathway. Therefore, the purpose of this study was to investigate whether rats and hamsters differ in lung iNOS expression in vivo upon exposure to asbestos fibers and whether differences in iNOS induction are associated with differences in the acute pulmonary inflammatory reaction. Body weight, alveolar-arterial oxygen difference, differential cell count in bronchoalveolar lavage fluid, total protein leakage, lung myeloperoxidase activity and lipidperoxidation, wet/dry ratio, iNOS mRNA and protein expression, and nitrotyrosine staining of lung tissue were determined 1 and 7 days after intratracheal instillation of asbestos fibers in CD rats and Syrian golden hamsters. Exposure of rats to asbestos fibers resulted in enhanced pulmonary iNOS expression and nitrotyrosine staining together with an acute inflammation that was characterized by an influx of neutrophils, enhanced myeloperoxidase activity and lipid peroxidation, damage of the alveolar-capillary membrane, edema formation, and impairment of gas exchange. In comparison, instillation of asbestos fibers in hamsters resulted in a significantly milder inflammatory reaction of the lung with no induction of iNOS in pulmonary cells. The data obtained provide important information to understand the underlying mechanisms of species differences in the pulmonary response upon exposure to asbestos fibers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
181
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-105
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12051993-Animals, pubmed-meshheading:12051993-Asbestos, Crocidolite, pubmed-meshheading:12051993-Asbestosis, pubmed-meshheading:12051993-Body Weight, pubmed-meshheading:12051993-Bronchoalveolar Lavage Fluid, pubmed-meshheading:12051993-Cell Count, pubmed-meshheading:12051993-Cricetinae, pubmed-meshheading:12051993-Disease Models, Animal, pubmed-meshheading:12051993-Inhalation Exposure, pubmed-meshheading:12051993-Intubation, Intratracheal, pubmed-meshheading:12051993-Lung, pubmed-meshheading:12051993-Mesocricetus, pubmed-meshheading:12051993-Nitric Oxide Synthase, pubmed-meshheading:12051993-Nitric Oxide Synthase Type II, pubmed-meshheading:12051993-Oxygen, pubmed-meshheading:12051993-Peroxidase, pubmed-meshheading:12051993-RNA, Messenger, pubmed-meshheading:12051993-Rats, pubmed-meshheading:12051993-Species Specificity, pubmed-meshheading:12051993-Thiobarbituric Acid Reactive Substances, pubmed-meshheading:12051993-Tyrosine
pubmed:year
2002
pubmed:articleTitle
Early inflammatory response to asbestos exposure in rat and hamster lungs: role of inducible nitric oxide synthase.
pubmed:affiliation
Institute for Surgical Research, University of Munich, Munich, Germany. doerger@icf.med.uni-muenchen.de
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't