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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2002-6-6
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pubmed:abstractText |
Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-10022537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-10721994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-10721995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-11017109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-11257134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-11312337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-11461707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-11581396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-11711593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-11884427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-1518869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-1596899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-7474080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-8653783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-9461435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-9525641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12050398-9988186
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CLEC4M protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/DC-specific ICAM-3 grabbing...,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6841-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12050398-Cell Adhesion Molecules,
pubmed-meshheading:12050398-Dendritic Cells,
pubmed-meshheading:12050398-Ebolavirus,
pubmed-meshheading:12050398-Humans,
pubmed-meshheading:12050398-Jurkat Cells,
pubmed-meshheading:12050398-Lectins,
pubmed-meshheading:12050398-Lectins, C-Type,
pubmed-meshheading:12050398-Monocytes,
pubmed-meshheading:12050398-Receptors, Antigen,
pubmed-meshheading:12050398-Receptors, Cell Surface,
pubmed-meshheading:12050398-Receptors, Virus,
pubmed-meshheading:12050398-Tumor Cells, Cultured,
pubmed-meshheading:12050398-Virion
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pubmed:year |
2002
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pubmed:articleTitle |
C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.
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pubmed:affiliation |
Laboratory of Molecular Microbiology, Dept. of Microbiology, Hospital 12 de Octubre, 28041 Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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