Source:http://linkedlifedata.com/resource/pubmed/id/12050184
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0005953,
umls-concept:C0038250,
umls-concept:C0079460,
umls-concept:C0143630,
umls-concept:C0178539,
umls-concept:C0439851,
umls-concept:C1332710,
umls-concept:C1515877,
umls-concept:C1516240,
umls-concept:C1552596,
umls-concept:C1704675,
umls-concept:C1879547,
umls-concept:C1947931,
umls-concept:C1948023
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| pubmed:issue |
6
|
| pubmed:dateCreated |
2002-6-6
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| pubmed:abstractText |
Recent studies have suggested the involvement of bone marrow in the pathogenesis of rheumatoid arthritis (RA), in which proliferation of monocyte-lineage cells (MLC) as well as local B cell activation in the synovium play an important role. Here, we show that bone marrow-derived MLC have the capacity to activate human peripheral blood IgD- B cells. Bone marrow CD34+ cells from RA patients that had been stimulated with stem cell factor and GM-CSF for 3-4 weeks (>90% CD14+ HLA-DR+ cells, <0.5% CD19+ B cells, and <0.5% CD3+ T cells; MLC) induced the production of IgG much more effectively than that of IgM by highly purified B cells from healthy donors in the presence of IL-2 and IL-10. CD34+ cells from cord blood or from bone marrow of osteoarthritis patients also displayed the capacity to induce IgG production. The induction of IgG production by the bone marrow-derived MLC was markedly decreased when they were separated from B cells by a membrane filter. The bone marrow-derived MLC interacted preferentially with IgD- B cells to induce IgG production. These results indicate that upon stimulation with stem cell factor and GM-CSF, CD34+ progenitor cells differentiate into MLC that activate preferentially IgD- B cells through direct cellular interactions to produce IgG. Therefore, the data suggest that the accelerated recruitment of MLC from the bone marrow to the synovium might play a role in the local B cell activation in RA.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
0741-5400
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
987-95
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12050184-Adult,
pubmed-meshheading:12050184-Aged,
pubmed-meshheading:12050184-Arthritis, Rheumatoid,
pubmed-meshheading:12050184-Arthroplasty, Replacement, Hip,
pubmed-meshheading:12050184-B-Lymphocytes,
pubmed-meshheading:12050184-Bone Marrow Cells,
pubmed-meshheading:12050184-Cell Differentiation,
pubmed-meshheading:12050184-Female,
pubmed-meshheading:12050184-Fetal Blood,
pubmed-meshheading:12050184-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:12050184-Humans,
pubmed-meshheading:12050184-Immunoglobulin D,
pubmed-meshheading:12050184-Infant, Newborn,
pubmed-meshheading:12050184-Male,
pubmed-meshheading:12050184-Middle Aged,
pubmed-meshheading:12050184-Monocytes,
pubmed-meshheading:12050184-Reference Values,
pubmed-meshheading:12050184-Stem Cell Factor,
pubmed-meshheading:12050184-T-Lymphocytes
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Bone marrow CD34+ progenitor cells stimulated with stem cell factor and GM-CSF have the capacity to activate IgD- B cells through direct cellular interaction.
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| pubmed:affiliation |
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan. shunsei@med.teikyo-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|