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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-6-6
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pubmed:abstractText |
The drs gene was isolated as a transformation suppressor against the v-src oncogene. Drs protein has a transmembrane domain and three consensus repeats (CRs) called Sushi motifs in the extracellular domain. The drs gene also has the ability to suppress anchorage-independent growth of human cancer cell lines. In this paper, we report the isolation of a novel variant cDNA of mouse drs (mDRS-2) containing two CRs, in addition to a mouse homolog of drs (mDRS-1) containing three CRs. We investigated the suppressor function of these mDRS cDNAs in human cancer cells and found that the lack of one CR is critical for suppression of anchorage-independent growth by drs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
183
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-86
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12049817-3T3 Cells,
pubmed-meshheading:12049817-Amino Acid Sequence,
pubmed-meshheading:12049817-Animals,
pubmed-meshheading:12049817-Base Sequence,
pubmed-meshheading:12049817-Cell Division,
pubmed-meshheading:12049817-Female,
pubmed-meshheading:12049817-Gene Library,
pubmed-meshheading:12049817-Genes, Tumor Suppressor,
pubmed-meshheading:12049817-Genes, src,
pubmed-meshheading:12049817-Genetic Variation,
pubmed-meshheading:12049817-Genetic Vectors,
pubmed-meshheading:12049817-Humans,
pubmed-meshheading:12049817-Membrane Proteins,
pubmed-meshheading:12049817-Mice,
pubmed-meshheading:12049817-Mice, Mutant Strains,
pubmed-meshheading:12049817-Molecular Sequence Data,
pubmed-meshheading:12049817-Ovary,
pubmed-meshheading:12049817-Retroviridae,
pubmed-meshheading:12049817-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12049817-Transfection,
pubmed-meshheading:12049817-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Isolation of a novel mouse variant of the drs tumor suppressor gene.
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pubmed:affiliation |
Division of Food Microbiology, Osaka Prefectural Institute of Public Health, Nakamichi, Higashinari-ku, 537-0025, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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