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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-6-6
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pubmed:abstractText |
IL-4 is important in Th2 differentiation and in cell expansion. Stat6 is necessary and sufficient for both functions. Although Gata3 is critical for Th2 polarization, it is not sufficient to mediate IL-4-driven cell expansion. We report that growth factor independent-1 (Gfi-1), a Stat6-dependent transcriptional repressor, strikingly increases Th2 cell expansion by promoting proliferation and preventing apoptosis. Cells infected with a Gfi-1 retrovirus show striking enhancement of IL-2-induced Stat5 phosphorylation and repression of p27(Kip-1) expression, suggesting a potential mechanism for the Gfi-1 growth effect. The synergy of Gfi-1 and Gata3 provides a mechanism through which IL-4 could selectively promote Th2 cell expansion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GATA3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Gata3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Gfi1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-44
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12049724-Animals,
pubmed-meshheading:12049724-Apoptosis,
pubmed-meshheading:12049724-Cells, Cultured,
pubmed-meshheading:12049724-Coculture Techniques,
pubmed-meshheading:12049724-DNA-Binding Proteins,
pubmed-meshheading:12049724-GATA3 Transcription Factor,
pubmed-meshheading:12049724-Genetic Vectors,
pubmed-meshheading:12049724-Interleukin-4,
pubmed-meshheading:12049724-Kinetics,
pubmed-meshheading:12049724-Lymphocyte Activation,
pubmed-meshheading:12049724-Mice,
pubmed-meshheading:12049724-Mice, Inbred BALB C,
pubmed-meshheading:12049724-Mice, Knockout,
pubmed-meshheading:12049724-Models, Immunological,
pubmed-meshheading:12049724-RNA, Messenger,
pubmed-meshheading:12049724-Retroviridae,
pubmed-meshheading:12049724-STAT6 Transcription Factor,
pubmed-meshheading:12049724-Th2 Cells,
pubmed-meshheading:12049724-Trans-Activators,
pubmed-meshheading:12049724-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation.
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pubmed:affiliation |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. jfzhu@niaid.nih.gov
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pubmed:publicationType |
Journal Article,
Comparative Study
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