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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-6-6
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pubmed:abstractText |
Endocytosed microbial antigens are primarily delivered to lysosomal compartments where antigen binding to MHC and CD1 molecules occurs in an acidic and proteolytically active environment. Signal-dependent delivery to lysosomes has been suggested for these antigen-presenting molecules, but molecular interactions with vesicular coat proteins and adaptors that direct their lysosomal sorting are poorly understood. Here CD1b but not other CD1 isoforms bound the AP-3 adaptor protein complex. In AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2 (HPS-2), CD1b failed to efficiently gain access to lysosomes, resulting in a profound defect in antigen presentation. Since MHC class II traffics normally in AP-3-deficient cells, defects in CD1b antigen presentation may account for recurrent bacterial infections in HPS-2 patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Vesicular...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD63,
http://linkedlifedata.com/resource/pubmed/chemical/CD1C protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CD1b antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CD63 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Monomeric Clathrin Assembly Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/clathrin assembly protein AP180
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
697-706
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12049721-Adaptor Proteins, Vesicular Transport,
pubmed-meshheading:12049721-Amino Acid Motifs,
pubmed-meshheading:12049721-Antigen Presentation,
pubmed-meshheading:12049721-Antigens, Bacterial,
pubmed-meshheading:12049721-Antigens, CD,
pubmed-meshheading:12049721-Antigens, CD1,
pubmed-meshheading:12049721-Antigens, CD63,
pubmed-meshheading:12049721-Bacterial Infections,
pubmed-meshheading:12049721-Carrier Proteins,
pubmed-meshheading:12049721-Cell Line,
pubmed-meshheading:12049721-Gene Deletion,
pubmed-meshheading:12049721-Glycoproteins,
pubmed-meshheading:12049721-HeLa Cells,
pubmed-meshheading:12049721-Humans,
pubmed-meshheading:12049721-Lipids,
pubmed-meshheading:12049721-Lysosomes,
pubmed-meshheading:12049721-Macromolecular Substances,
pubmed-meshheading:12049721-Membrane Proteins,
pubmed-meshheading:12049721-Monomeric Clathrin Assembly Proteins,
pubmed-meshheading:12049721-Platelet Membrane Glycoproteins,
pubmed-meshheading:12049721-Protein Isoforms,
pubmed-meshheading:12049721-Protein Transport,
pubmed-meshheading:12049721-Syndrome
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pubmed:year |
2002
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pubmed:articleTitle |
Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells.
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pubmed:affiliation |
Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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