Linked Life Data

1204836

Source:http://linkedlifedata.com/resource/pubmed/id/1204836

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1976-3-15
pubmed:abstractText
Bombesin is a tetradecapeptide extracted from the side of discoglossid frogs Bombina bombina and Bombina variegata variegata. In anaesthetized dogs bombesin causes mainly systemic hypertension, bradycardia and constriction of the renal, mesenteric and coeliac arterial vessels. The other vascular beds studied (carotid, femoral and coronaric) passively follow the blood pressure. Tachyphylaxis may occur. Dibenzyline and hexamethonium do not antagonize the hypertensive property of bombesin, while the occlusion either of the renal vessels or of the mesenteric, coeliac arteries and portal vein reduces the intensity and the duration of the hypertensive response. The simultaneous occlusion of all the above mentioned vessels further reduces the duration of the hypertensive response evoked by bombesin and reverses its effect on the heart from mainly bradycardic to pure tachycardic. In these condition bombesin causes carotid and peripheral vasoconstriction. The increase of heart rate and of blood pressure, while occurs after ligation of aplanchnic vessels, is completely or partly antagonized by propranolol. In normal conscious dogs bombesin is at least 10 times more potent and less tachyphylactic than in anesthetized dogs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0430-0920
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
983-91
pubmed:dateRevised
2009-6-5
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Cardiovascular pharmacology of bombesin, a new polypeptide from amphibian skin.
pubmed:publicationType
Journal Article