Linked Life Data

12048242

Source:http://linkedlifedata.com/resource/pubmed/id/12048242

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2002-6-12
pubmed:abstractText
Rod cyclic nucleotide-gated (CNG) channels are heterotetramers comprised of both CNGA1 and CNGB1 subunits. Calcium/calmodulin (Ca(2+)/CaM) binds to a site in the N-terminal region of CNGB1 subunits and inhibits the opening conformational change in CNGA1/CNGB1 channels. Here, we show that polypeptides derived from an N-terminal region of CNGB1 form a specific interaction with polypeptides derived from a C-terminal region of CNGA1 that is distal to the cyclic nucleotide-binding domain. Deletion of the Ca(2+)/CaM-binding site from the N-terminal region of CNGB1 eliminated both Ca(2+)/CaM modulation of the channel and the intersubunit interaction. Furthermore, the interaction was disrupted by the presence of Ca(2+)/CaM. These results suggest that Ca(2+)/CaM-dependent inhibition of rod channels is caused by the direct binding of Ca(2+)/CaM to a site in the N-terminal region in CNGB1, which disrupts the interaction between this region and a distal C-terminal region of CNGA1. The mechanism underlying Ca(2+)/CaM modulation of rod channels is distinct from that in olfactory (CNGA2) CNG channels.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-10051660, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-10197534, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-10228178, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-10230783, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-10377344, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-10448166, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-10482246, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-10639176, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-11087347, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-11739959, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-11739960, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-11764791, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-11970862, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-1281886, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-1694264, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-1697649, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-2481236, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-2578616, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-2828639, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-3027574, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-6270629, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7473217, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7511217, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7525588, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7526466, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7530019, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7541117, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7541463, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7546742, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7638597, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7678445, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-7682292, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-8201981, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-8630256, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-8744304, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-8833443, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-8865065, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9034189, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9141499, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9278419, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9311913, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9512030, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9535905, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9539801, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9545240, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9728925, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9774106, http://linkedlifedata.com/resource/pubmed/commentcorrection/12048242-9806963
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8424-9
pubmed:dateRevised
2011-3-9
pubmed:meshHeading
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