Linked Life Data

12048170

Source:http://linkedlifedata.com/resource/pubmed/id/12048170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-6-5
pubmed:abstractText
The effect of exogenous melatonin (MEL) on the circadian system in nocturnal species has been extensively studied, but little is known about its chronobiotic effect in diurnal mammals. The present study investigated the effect of exogenous MEL on the circadian locomotor activity rhythm in the diurnal rodent Arvicanthis ansorgei. Male animals (n=34) were fitted with a subcutaneous catheter for daily infusion of MEL (1 h; 100 microg) and their running wheel activity was recorded. The results showed that administration of MEL to animals free-running in DD entrained their activity rhythm by phase advances at circadian time (CT) 10.62, and by phase delays at CT -0.40 (CT 0, activity onset). The range of entrainment was 17 and 11.5 min for advance and delay stimuli, respectively. Interestingly, in the nocturnal rat and the A. ansorgei, entrainment of the activity rhythm to exogenous MEL by phase advances occurs at exactly the same phase of the circadian cycle. In both nocturnal and diurnal species, the sensitivity window for exogenous MEL is located near the activity/rest transition points. It is concluded that the functional properties of entrainment to exogenous MEL are similar to those of other nonphotic stimuli. Furthermore, A. ansorgei might be an interesting animal model for studies on the chronobiotic effects of exogenous MEL in diurnal mammals including humans.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Daily infusion of melatonin entrains circadian activity rhythms in the diurnal rodent Arvicanthis ansorgei.
pubmed:affiliation
ULP UMR-CNRS 7518, Lab de Neurobiologie des Fonctions Rythmiques et Saisonnières, Université Louis Pasteur, 12 rue de l'Université, FR-67000 Strasbourg, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't