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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9317
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pubmed:dateCreated |
2002-6-5
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pubmed:abstractText |
Streptococcus pneumoniae is a major cause of morbidity and mortality in developed and developing countries. No common genetic determinants of susceptibility have been defined. Mannose-binding lectin (MBL) is a key mediator of innate host immunity that activates the complement pathway and directly opsonises some infectious pathogens. Mutations in three codons in the MBL gene have been identified, and individuals homozygous for a mutant genotype have very little or no serum MBL. We did a case-control study in the UK to assess whether these mutant genotypes were associated with invasive pneumococcal disease.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0140-6736
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pubmed:author |
pubmed-author:CrookDerrick WDW,
pubmed-author:DayNicholas PNP,
pubmed-author:DinM UMU,
pubmed-author:GriffithsDavidD,
pubmed-author:HillAdrian V SAV,
pubmed-author:McPheatWilliam LWL,
pubmed-author:MooreCatrin ECE,
pubmed-author:Oxford Pneumoccocal Surveillance Group,
pubmed-author:RoySuchismitaS,
pubmed-author:SegalShelleyS,
pubmed-author:SmarasonAlexA,
pubmed-author:WelshKenneth IKI
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
359
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1569-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12047967-Adult,
pubmed-meshheading:12047967-Aged,
pubmed-meshheading:12047967-Carrier Proteins,
pubmed-meshheading:12047967-Case-Control Studies,
pubmed-meshheading:12047967-Chi-Square Distribution,
pubmed-meshheading:12047967-Codon,
pubmed-meshheading:12047967-Collectins,
pubmed-meshheading:12047967-Female,
pubmed-meshheading:12047967-Genetic Predisposition to Disease,
pubmed-meshheading:12047967-Great Britain,
pubmed-meshheading:12047967-Homozygote,
pubmed-meshheading:12047967-Humans,
pubmed-meshheading:12047967-Logistic Models,
pubmed-meshheading:12047967-Male,
pubmed-meshheading:12047967-Middle Aged,
pubmed-meshheading:12047967-Pneumococcal Infections,
pubmed-meshheading:12047967-Polymorphism, Genetic,
pubmed-meshheading:12047967-Risk Factors,
pubmed-meshheading:12047967-Statistics, Nonparametric,
pubmed-meshheading:12047967-Streptococcus pneumoniae
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pubmed:year |
2002
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pubmed:articleTitle |
MBL genotype and risk of invasive pneumococcal disease: a case-control study.
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pubmed:affiliation |
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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