Source:http://linkedlifedata.com/resource/pubmed/id/12047922
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2002-6-5
|
pubmed:abstractText |
Models of HIV-1 infection that include intracellular delays are more accurate representations of the biology and change the estimated values of kinetic parameters when compared to models without delays. We develop and analyze a set of models that include intracellular delays, combination antiretroviral therapy, and the dynamics of both infected and uninfected T cells. We show that when the drug efficacy is less than perfect the estimated value of the loss rate of productively infected T cells, delta, is increased when data is fit with delay models compared to the values estimated with a non-delay model. We provide a mathematical justification for this increased value of delta. We also provide some general results on the stability of non-linear delay differential equation infection models.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0025-5564
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
179
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
73-94
|
pubmed:dateRevised |
2009-11-11
|
pubmed:meshHeading |
pubmed-meshheading:12047922-Antiviral Agents,
pubmed-meshheading:12047922-HIV Infections,
pubmed-meshheading:12047922-HIV-1,
pubmed-meshheading:12047922-Humans,
pubmed-meshheading:12047922-Models, Biological,
pubmed-meshheading:12047922-Numerical Analysis, Computer-Assisted,
pubmed-meshheading:12047922-T-Lymphocytes,
pubmed-meshheading:12047922-Viral Load
|
pubmed:articleTitle |
Mathematical analysis of delay differential equation models of HIV-1 infection.
|
pubmed:affiliation |
Department of Mathematics, The University of Michigan, 525 E. University, 3071 E. Hall, Ann Arbor, MI 48109-1109, USA. pwn@math.lsa.umich.edu
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|