Linked Life Data

1204577

Source:http://linkedlifedata.com/resource/pubmed/id/1204577

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1976-4-2
pubmed:abstractText
The vitamin D3 derivatives, 1alpha-hydroxyvitamin D3; 1alpha-hydroxy-3-deoxyvitamin D3; 5,6-trans-vitamin D3; and 5,6-trans-25-hydroxyvitamin D3 were tested for bone resorbing activity in vitro. 1alpha-Hydroxy-3-deoxyvitamin D3 and 5,6-trans-vitamin D3 were inactive at concentrations as high as 10(-6)M. 1alpha-Hydroxyvitamin D3 had significant effects on mineral and matrix resorption at concentrations of 2.5 X 10(-8)M and above, and was 2-3 orders of magnitude less potent than 1,25-dihydroxyvitamin D3 in this system. A concentration of 2.5 X 10(-7)M of 5,6-trans-25-hydroxyvitamin D3 was required to stimulate 45Ca release. The results indicate that 1) in the vitamin D3 series of compounds the presence of only one hydroxyl group in the molecule in either the 1alpha or the 3beta position in the A ring results in a compound with very limited or no direct effects on bone, and 2) the direct effects of vitamin D3 congeners on bone resorption do not require the presence of a 25-hydroxy group, but their activity is markedly enhanced by the 25-hydroxy group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1552-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Bone resorbing activity of vitamin D metabolites and congeners in vitro: influence of hydroxyl substituents in the A ring.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.