Linked Life Data

12045255

Source:http://linkedlifedata.com/resource/pubmed/id/12045255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2002-6-4
pubmed:abstractText
Renin is an aspartyl protease essential for the control of blood pressure and was long suspected to have cellular receptors. We report the expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a single transmembrane domain and no homology with any known membrane protein. Transfected cells stably expressing the receptor showed renin- and prorenin-specific binding. The binding of renin induced a fourfold increase of the catalytic efficiency of angiotensinogen conversion to angiotensin I and induced an intracellular signal with phosphorylation of serine and tyrosine residues associated to an activation of MAP kinases ERK1 and ERK2. High levels of the receptor mRNA are detected in the heart, brain, placenta, and lower levels in the kidney and liver. By confocal microscopy the receptor is localized in the mesangium of glomeruli and in the subendothelium of coronary and kidney artery, associated to smooth muscle cells and colocalized with renin. The renin receptor is the first described for an aspartyl protease. This discovery emphasizes the role of the cell surface in angiotensin II generation and opens new perspectives on the tissue renin-angiotensin system and on renin effects independent of angiotensin II.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10325244, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10354703, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10403605, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10419812, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10506489, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10541290, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10617578, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10635057, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10736279, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10755467, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10856276, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10880053, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10889139, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10949579, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10978898, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-10986153, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-11001069, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-11254670, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-12696559, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-1829461, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-20242, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-2407520, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-7108955, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-7744780, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-7814847, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-8642790, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-8663114, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-8735181, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-8814748, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-8864727, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-8903314, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-8943472, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-9012744, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-9172787, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-9403558, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-9466969, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-9556572, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045255-9857376
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin I, http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II, http://linkedlifedata.com/resource/pubmed/chemical/Calcium, http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/DNA, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface, http://linkedlifedata.com/resource/pubmed/chemical/Renin, http://linkedlifedata.com/resource/pubmed/chemical/Vacuolar Proton-Translocating...
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1417-27
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
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