Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-6-4
pubmed:abstractText
The "knockout-rate" prediction holds that essential genes should be more evolutionarily conserved than are nonessential genes. This is because negative (purifying) selection acting on essential genes is expected to be more stringent than that for nonessential genes, which are more functionally dispensable and/or redundant. However, a recent survey of evolutionary distances between Saccharomyces cerevisiae and Caenorhabditis elegans proteins did not reveal any difference between the rates of evolution for essential and nonessential genes. An analysis of mouse and rat orthologous genes also found that essential and nonessential genes evolved at similar rates when genes thought to evolve under directional selection were excluded from the analysis. In the present study, we combine genomic sequence data with experimental knockout data to compare the rates of evolution and the levels of selection for essential versus nonessential bacterial genes. In contrast to the results obtained for eukaryotic genes, essential bacterial genes appear to be more conserved than are nonessential genes over both relatively short (microevolutionary) and longer (macroevolutionary) time scales.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-10421576, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-10592175, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-10710307, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-10761919, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-10837241, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-11125040, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-11206551, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-11429604, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-1583694, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-2231712, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-2842773, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-409339, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-7984417, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-8308912, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-8433381, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-8487630, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-8587116, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-9252185, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-9254694, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-9278503, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-9322058, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-9381173, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-9689093, http://linkedlifedata.com/resource/pubmed/commentcorrection/12045149-9923682
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1088-9051
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
962-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Essential genes are more evolutionarily conserved than are nonessential genes in bacteria.
pubmed:affiliation
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
pubmed:publicationType
Journal Article