Linked Life Data

12044647

Source:http://linkedlifedata.com/resource/pubmed/id/12044647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-6-4
pubmed:abstractText
We recently reported that perfusion of tetrodotoxin (TTX) into the preoptic area and anterior hypothalamus (PO/AH), by using a microdialysis technique, induced an increase in body temperature (Tb) under normal and hot ambient temperatures (23 and 35 degrees C) in freely moving rats. However, the procedure had no effect on Tb under a cold ambient temperature (5 degrees C). The present study was designed to determine the mechanism(s) of increases in Tb after perfusion of TTX into the PO/AH, by measuring tail skin temperature (Ttail) as an index of heat loss, and heart rate (HR) and locomotor activity (Act) as indexes of heat production, under three ambient temperatures. Under normal ambient temperature (23 degrees C), perfusion of TTX induced significant hyperthermia with increased HR, Act and Ttail. In a hot environment (35 degrees C), perfusion of TTX induced a greater increase in Tb with increased HR but no change in Ttail and Act. In a cold environment (5 degrees C), perfusion of TTX had no effect on Tb with a slight increase in Act but no change in HR and Ttail. Our results suggest that the PO/AH may be involved in inhibition of heat production and excitation/inhibition of the tail vasomotor tone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
325
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Functional role of the preoptic area and anterior hypothalamus in thermoregulation in freely moving rats.
pubmed:affiliation
Department of Biology, Graduate School of Science, Tokyo Metropolitan University, 1-1 Minami-ohsawa, Hachioji, Tokyo 192-0397, Japan. ishiwata@comp.metro-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't