|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2002-6-4
|
|
pubmed:abstractText |
Ginsenosides are known to attenuate glutamate-induced cell injuries in vitro. We investigated the in vivo effect of ginsenosides on kainic acid (KA)-induced neurotoxicity in rat hippocampus using the methods of acid fuchsin (AF) staining and heat-shock protein-70 (HSP-70) immunoreactivity to detect neuronal death and stress, respectively. Pretreatment of ginsenosides (50 or 100 mg/kg for 7 days) via intraperitoneal (i.p.) administration significantly attenuated KA (10 mg/kg i.p.)-induced cell death by decreasing AF-positive neurons in both CA1 and CA3 regions of rat hippocampus compared with KA treatment alone. Pretreatment of ginsenosides (50 or 100 mg/kg for 7 days) via i.p. administration also significantly suppressed KA-induced induction of HSP-70 in both regions of rat hippocampus. These results show that ginsenosides are effective in protecting hippocampal CA1 and CA3 cells against KA-induced neurotoxicity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0304-3940
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
325
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
129-33
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12044638-Animals,
pubmed-meshheading:12044638-Benzenesulfonates,
pubmed-meshheading:12044638-Cell Death,
pubmed-meshheading:12044638-Coloring Agents,
pubmed-meshheading:12044638-Ginsenosides,
pubmed-meshheading:12044638-HSP70 Heat-Shock Proteins,
pubmed-meshheading:12044638-Hippocampus,
pubmed-meshheading:12044638-Immunologic Techniques,
pubmed-meshheading:12044638-Kainic Acid,
pubmed-meshheading:12044638-Male,
pubmed-meshheading:12044638-Neuroprotective Agents,
pubmed-meshheading:12044638-Neurotoxins,
pubmed-meshheading:12044638-Oxidative Stress,
pubmed-meshheading:12044638-Panax,
pubmed-meshheading:12044638-Rats,
pubmed-meshheading:12044638-Rats, Sprague-Dawley,
pubmed-meshheading:12044638-Saponins,
pubmed-meshheading:12044638-Staining and Labeling
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Protective effect of ginsenosides, active ingredients of Panax ginseng, on kainic acid-induced neurotoxicity in rat hippocampus.
|
|
pubmed:affiliation |
Department of Anatomy, College of Veterinary Medicine, Chonnam National University, Kwangju 500-757, South Korea.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
