Linked Life Data

12043216

Source:http://linkedlifedata.com/resource/pubmed/id/12043216

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-6-4
pubmed:abstractText
Evidenced-based medicine(EBM) is undergoing rapid acceptance as a principle of decision making in radiation oncology clinics. Adjuvant therapy for breast cancer is one of the most actively researched areas, and there is a great deal of clinical evidence of high-quality treatment of breast cancer. The case of 47-year-old premenopausal woman who underwent consultation for postmastectomy radiotherapy (PMRT) is presented, and the course of practice using EBM is described. Because she had one positive axillary lymph node, she received systemic chemotherapy with doxorubicin, cyclophosphamide, and paclitaxel. She is also receiving trastuzumab and tamoxifen. She underwent immediate reconstruction with a TRAM flap. Existing guidelines point out that PMRT significantly reduces the risk of local recurrence; however, none of them recommend PMRT for a patient with < 4 positive lymph nodes because of the lack of firm evidence for improvement of overall survival. There is also some evidence that PMRT after immediate reconstruction reduces the cosmetic result and that paclitaxel might increase the risk of radiation pneumonitis even in sequential administration. She chose PMRT, although our recommendation was not to do so. Expertise in the area of breast cancer as well as high-level evidence developed in Japan is essential to effectively implement EBM.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0048-0428
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
138-43
pubmed:dateRevised
2011-7-26
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[Current status of radiation therapy--evidence-based medicine (EBM) of radiation therapy. Breast cancer].
pubmed:affiliation
Department of Therapeutic Radiology and Oncology, Graduate School of Medicine, Kyoto University.
pubmed:publicationType
Journal Article, English Abstract, Review, Case Reports