| pubmed-article:12042673 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12042673 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12042673 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:12042673 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:12042673 | lifeskim:mentions | umls-concept:C0919427 | lld:lifeskim |
| pubmed-article:12042673 | lifeskim:mentions | umls-concept:C0023746 | lld:lifeskim |
| pubmed-article:12042673 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:12042673 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:12042673 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12042673 | pubmed:dateCreated | 2002-6-3 | lld:pubmed |
| pubmed-article:12042673 | pubmed:abstractText | A common polymorphism in a folate-metabolizing gene, methylenetetrahydrofolate reductase (MTHFR) 677C>T has been associated with reduced risk of colorectal cancer. In this study, we investigated whether a second common polymorphism of the gene, MTHFR 1298A>C, is an independent risk factor for colorectal cancer and if it is associated with plasma folate and total homocysteine (tHcy) levels. We also examined whether the 677C>T and 1298A>C polymorphisms are in linkage disequilibrium and whether combined heterozygosity confers additional (or reduced) risk of colorectal cancer. We conducted a nested case-control study of 211 incident colorectal cancer cases and 343 controls in the prospective Physicians' Health Study. The MTHFR 677C>T and 1298A>C polymorphisms were in linkage disequilibrium in this population. Compared to MTHFR 1298AA genotype, multivariate-adjusted relative risk of colorectal cancer was 0.73 (95% CI 0.37-1.43) for the MTHFR 1298CC genotype. The slight reduction in risk was not a result of its linkage disequilibrium with the 677C>T polymorphism. This polymorphism was not significantly correlated with the plasma folate and tHcy levels. The combined heterozygosity did not modify the cancer risk; nor did it change the plasma folate and tHcy significantly. We conclude that the MTHFR 1298A>C polymorphism is a less substantial independent risk factor for colorectal cancer compared to the 677C>T polymorphism. | lld:pubmed |
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| pubmed-article:12042673 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12042673 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12042673 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12042673 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12042673 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12042673 | pubmed:issn | 0960-314X | lld:pubmed |
| pubmed-article:12042673 | pubmed:author | pubmed-author:SelhubJacobJ | lld:pubmed |
| pubmed-article:12042673 | pubmed:author | pubmed-author:MaJingJ | lld:pubmed |
| pubmed-article:12042673 | pubmed:author | pubmed-author:StampferMeir... | lld:pubmed |
| pubmed-article:12042673 | pubmed:author | pubmed-author:ChenJiaJ | lld:pubmed |
| pubmed-article:12042673 | pubmed:author | pubmed-author:HunterDavid... | lld:pubmed |
| pubmed-article:12042673 | pubmed:author | pubmed-author:PalomequeCaro... | lld:pubmed |
| pubmed-article:12042673 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12042673 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12042673 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12042673 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12042673 | pubmed:pagination | 339-42 | lld:pubmed |
| pubmed-article:12042673 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12042673 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12042673 | pubmed:articleTitle | Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer. | lld:pubmed |
| pubmed-article:12042673 | pubmed:affiliation | Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY, USA. jia.chen@mssm.edu | lld:pubmed |
| pubmed-article:12042673 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12042673 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12042673 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12042673 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
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