12041951

Source:http://linkedlifedata.com/resource/pubmed/id/12041951

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001554, umls-concept:C0011900, umls-concept:C0030705, umls-concept:C0752335, umls-concept:C1273870
pubmed:issue	2
pubmed:dateCreated	2002-6-3
pubmed:abstractText	Neuropsychiatric systemic lupus erythematosus (NPSLE) involves a wide range of focal and diffuse central and peripheral nervous system disorders and affects up to 75% of SLE patients. NPSLE can occur any time in the course of SLE, even during periods in which no SLE disease activity is detected, and is likely to be caused by multiple factors, including autoantibody production, microvasculopathy and pro-inflammatory cytokines. Central to the diagnosis of NPSLE is the question of whether the presenting neuropsychiatric symptoms are due to SLE-mediated organ dysfunction, infection, medication side-effects or metabolic abnormalities (e.g. uraemia), or are due to an unrelated condition. The diagnostic inference of NPSLE can be made only after these secondary causes have been excluded. There is no one single diagnostic tool specific to NPSLE, and clinical diagnostic impressions must be based on the combined use of immunoserological testing, functional and/or structural neuroimaging and standardized neurological, rheumatological, psychiatric and neuropsychological assessments. The management of NPSLE includes symptomatic and/or immunosuppressive treatment strategies depending on the specific presenting neuropsychiatric symptoms and whether these occur in the setting of an SLE disease activity flare.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101121149
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1521-6942
pubmed:author	pubmed-author:BreyRobin LRL, pubmed-author:Hermosillo-RomoDavidD
pubmed:copyrightInfo	Copyright 2002 Elsevier Science Ltd.
pubmed:issnType	Print
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	229-44
pubmed:dateRevised	2005-11-16
pubmed:meshHeading	pubmed-meshheading:12041951-Humans, pubmed-meshheading:12041951-Lupus Vasculitis, Central Nervous System, pubmed-meshheading:12041951-Physician's Practice Patterns
pubmed:year	2002
pubmed:articleTitle	Diagnosis and management of patients with neuropsychiatric systemic lupus erythematosus (NPSLE).
pubmed:affiliation	Division of Neurology 7883, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, USA.
pubmed:publicationType	Journal Article, Review