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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-5-31
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pubmed:abstractText |
The aetiology of chronic prostatitis is not understood. The aim of this study is to investigate an autoimmune hypothesis by looking for T cell proliferation in response to proteins of the seminal plasma. We studied peripheral blood mononuclear cell proliferation from 20 patients with chronic prostatitis and 20 aged-matched controls in response to serial dilutions of seminal plasma (SP) from themselves (autologous SP) and from a healthy individual without the disease (allo-SP). We found that the patients have a statistically greater lymphocyte proliferation to autologous SP at the 1/50 dilution on day 6 compared to controls (P = 0 x 01). They also have a greater proliferation to allo-SP on both day 5 (P = 0 x 001) and day 6 (P = 0 x 01) at the same dilution. Using a stimulation index (SI) of 9 to either autologous SP or allo-SP on day 6 at the 1/50 dilution as a definition of a proliferative response to SP, then 13/20 patients as compared to 3/20 controls showed a proliferative response to SP (P = 0 x 003, Fishers exact test). These data support an autoimmune hypothesis for chronic prostatitis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-10096371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-10411041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-10569559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-10604329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-10604335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-10861757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-10992370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-11125356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-11173942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-1747961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-2196972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-2581721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-2702780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-3371978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-3537628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-3761274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-3838947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-4870505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-4960148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-7990073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-8201676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-8583619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-8940458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-9426720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-9507840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-9629442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12041509-9730454
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
302-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12041509-Adult,
pubmed-meshheading:12041509-Autoimmunity,
pubmed-meshheading:12041509-Chronic Disease,
pubmed-meshheading:12041509-Humans,
pubmed-meshheading:12041509-Lymphocyte Activation,
pubmed-meshheading:12041509-Male,
pubmed-meshheading:12041509-Middle Aged,
pubmed-meshheading:12041509-Pelvic Pain,
pubmed-meshheading:12041509-Prostatitis,
pubmed-meshheading:12041509-Semen,
pubmed-meshheading:12041509-Syndrome,
pubmed-meshheading:12041509-T-Lymphocytes
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pubmed:year |
2002
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pubmed:articleTitle |
Autoimmune T cell responses to seminal plasma in chronic pelvic pain syndrome (CPPS).
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pubmed:affiliation |
Department of Urology, Addenbrooke's Hospital, Cambridge, UK. grd@batstoner.fsnet.co.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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