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12039570
Source:
http://linkedlifedata.com/resource/pubmed/id/12039570
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46
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Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0021701
,
umls-concept:C0209606
,
umls-concept:C0243072
,
umls-concept:C0243076
,
umls-concept:C1172483
pubmed:issue
12
pubmed:dateCreated
2002-5-31
pubmed:abstractText
The SAR studies to optimise both potency and rate of clearance in the rat for a series of pyrimidine and pyridine based VLA-4 antagonists are described.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha4beta1
,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylalanine
,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines
,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0960-894X
pubmed:author
pubmed-author:ArchibaldSarah CSC
,
pubmed-author:BrownJulien AJA
,
pubmed-author:ChildsKirstieK
,
pubmed-author:CritchleyDavidD
,
pubmed-author:HeadJohn CJC
,
pubmed-author:HutchinsonBrianB
,
pubmed-author:PartonTed A HTA
,
pubmed-author:PorterJohn RJR
,
pubmed-author:RobinsonMartyn KMK
,
pubmed-author:ShockAnthonyA
,
pubmed-author:WarrellowGraham JGJ
,
pubmed-author:ZomayaAlexA
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1595-8
pubmed:meshHeading
pubmed-meshheading:12039570-Integrin alpha4beta1
,
pubmed-meshheading:12039570-Phenylalanine
,
pubmed-meshheading:12039570-Pyridines
,
pubmed-meshheading:12039570-Pyrimidines
,
pubmed-meshheading:12039570-Structure-Activity Relationship
pubmed:year
2002
pubmed:articleTitle
N-(pyrimidin-4-yl) and N-(pyridin-2-yl) phenylalanine derivatives as VLA-4 integrin antagonists.
pubmed:affiliation
Celltech R&D Ltd, 216 Bath Road, SL1 4EN, Slough, UK. john.porter@celltechgroup.com
pubmed:publicationType
Journal Article