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rdf:type |
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lifeskim:mentions |
umls-concept:C0205177,
umls-concept:C0205464,
umls-concept:C0205531,
umls-concept:C0220781,
umls-concept:C0226896,
umls-concept:C0442027,
umls-concept:C1171350,
umls-concept:C1366876,
umls-concept:C1527415,
umls-concept:C1833235,
umls-concept:C1880022,
umls-concept:C1883254
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pubmed:issue |
12
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pubmed:dateCreated |
2002-5-31
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pubmed:abstractText |
Inhibitors of the MAP kinase p38 provide a novel approach for the treatment of osteoporosis, inflammatory disorders, and cancer. We have identified N-(3-tert-butyl-1-methyl-5-pyrazolyl)-N'-(4-(4-pyridinylmethyl)phenyl)urea as a potent and selective p38 kinase inhibitor in biochemical and cellular assays. This compound is orally active in two acute models of cytokine release (TNF-induced IL-6 and LPS-induced TNF) and a chronic model of arthritis (20-day murine collagen-induced arthritis).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BankstonDonaldD,
pubmed-author:BhargavaAjayA,
pubmed-author:BortolonElizabethE,
pubmed-author:CaringalYolandaY,
pubmed-author:ChauThuyT,
pubmed-author:ChienDu-ShiengDS,
pubmed-author:CooleyJeffreyJ,
pubmed-author:DumasJacquesJ,
pubmed-author:Gianpaolo OstravageCynthiaC,
pubmed-author:GunnDavidD,
pubmed-author:Hatoum-MokdadHoliaH,
pubmed-author:HousleyTimothy JTJ,
pubmed-author:MuzsiAndrewA,
pubmed-author:NagleR CRC,
pubmed-author:OsterhoutMartinM,
pubmed-author:PaulsenHolgerH,
pubmed-author:PirroJohnJ,
pubmed-author:RangesGerald EGE,
pubmed-author:RedmanAniko MAM,
pubmed-author:SchoenleberRobertR,
pubmed-author:ScottWilliam JWJ,
pubmed-author:ShrikhandeAlkaA,
pubmed-author:SibleyRobert NRN,
pubmed-author:SmithRoger ARA,
pubmed-author:VEYE KEK,
pubmed-author:WakefieldJeanJ,
pubmed-author:WentzR MRM,
pubmed-author:WilhelmScott MSM,
pubmed-author:WolaninDonaldD,
pubmed-author:WoodJillJ
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1559-62
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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pubmed:year |
2002
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pubmed:articleTitle |
Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor.
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pubmed:affiliation |
Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. jacques.dumas.b@bayer.com
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pubmed:publicationType |
Journal Article
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