|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2002-5-30
|
|
pubmed:abstractText |
Peanut allergy is a major health concern due to the increased prevalence, potential severity, and chronicity of the reaction. The cDNA encoding a third peanut allergen, Ara h 3, has been previously cloned and characterized. Mutational analysis of the Ara h 3 IgE-binding epitopes with synthetic peptides revealed that single amino acid changes at critical residues could diminish IgE binding.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1018-2438
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
128
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
15-23
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:12037397-Allergens,
pubmed-meshheading:12037397-Amino Acid Sequence,
pubmed-meshheading:12037397-Antigens, Plant,
pubmed-meshheading:12037397-Blotting, Western,
pubmed-meshheading:12037397-Humans,
pubmed-meshheading:12037397-Hypersensitivity, Immediate,
pubmed-meshheading:12037397-Immunoglobulin E,
pubmed-meshheading:12037397-Lymphocyte Activation,
pubmed-meshheading:12037397-Molecular Sequence Data,
pubmed-meshheading:12037397-Mutagenesis, Site-Directed,
pubmed-meshheading:12037397-Peanut Hypersensitivity,
pubmed-meshheading:12037397-Polymerase Chain Reaction,
pubmed-meshheading:12037397-Recombinant Proteins,
pubmed-meshheading:12037397-Seed Storage Proteins,
pubmed-meshheading:12037397-T-Lymphocytes
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Modification of peanut allergen Ara h 3: effects on IgE binding and T cell stimulation.
|
|
pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Arkansas Children's Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
