| pubmed-article:12036602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0036111 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0036953 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C1282910 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:12036602 | lifeskim:mentions | umls-concept:C0442117 | lld:lifeskim |
| pubmed-article:12036602 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12036602 | pubmed:dateCreated | 2002-5-30 | lld:pubmed |
| pubmed-article:12036602 | pubmed:abstractText | An immunization strategy using attenuated bacteria to deliver DNA vaccine plasmids to mucosal sites may induce protective T cell responses against sexual HIV transmission. In a murine intranasal (i.n.) immunization model, we demonstrate that transiently persistent Deltaasd Shigella flexneri strain 15D harboring DNA vaccines induces HIV- and SIV-specific gamma interferon (IFN-gamma) producing CD8+ T cells among splenocytes more efficiently than either a longer persisting DeltaaroD Salmonella typhimurium strain SL7207 or transiently persistent S. typhi strain Ty21a harboring DNA vaccines. Also, the frequency of antigen-specific gamma interferon (IFN-gamma) producing cells induced by Shigella 15D harboring a DNA vaccine were comparable to that induced by intramuscular (i.m.) immunization with purified DNA vaccine. Moreover, the magnitude of mucosal and systemic antigen-specific IgA and IgG responses after immunization were dependent upon the route (i.m. vs. i.n.) of inoculation, with i.n. Shigella 15D DNA vaccines generating higher levels of HIV-specific IgA in vaginal washings than i.m. purified DNA vaccine. Deltaasd S. flexneri is a promising vector for mucosal DNA vaccine immunization against HIV. | lld:pubmed |
| pubmed-article:12036602 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12036602 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12036602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12036602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12036602 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12036602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12036602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12036602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12036602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12036602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12036602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12036602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12036602 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12036602 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:12036602 | pubmed:author | pubmed-author:JacobsWilliam... | lld:pubmed |
| pubmed-article:12036602 | pubmed:author | pubmed-author:VecinoWilliam... | lld:pubmed |
| pubmed-article:12036602 | pubmed:author | pubmed-author:MorinPaul MPM | lld:pubmed |
| pubmed-article:12036602 | pubmed:author | pubmed-author:AghaRabiaR | lld:pubmed |
| pubmed-article:12036602 | pubmed:author | pubmed-author:FennellyGlenn... | lld:pubmed |
| pubmed-article:12036602 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12036602 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:12036602 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:12036602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12036602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12036602 | pubmed:pagination | 197-204 | lld:pubmed |
| pubmed-article:12036602 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:12036602 | pubmed:meshHeading | pubmed-meshheading:12036602... | lld:pubmed |
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| pubmed-article:12036602 | pubmed:meshHeading | pubmed-meshheading:12036602... | lld:pubmed |
| pubmed-article:12036602 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12036602 | pubmed:articleTitle | Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV. | lld:pubmed |
| pubmed-article:12036602 | pubmed:affiliation | Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. | lld:pubmed |
| pubmed-article:12036602 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12036602 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12036602 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12036602 | lld:pubmed |
