Source:http://linkedlifedata.com/resource/pubmed/id/12036602
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2002-5-30
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| pubmed:abstractText |
An immunization strategy using attenuated bacteria to deliver DNA vaccine plasmids to mucosal sites may induce protective T cell responses against sexual HIV transmission. In a murine intranasal (i.n.) immunization model, we demonstrate that transiently persistent Deltaasd Shigella flexneri strain 15D harboring DNA vaccines induces HIV- and SIV-specific gamma interferon (IFN-gamma) producing CD8+ T cells among splenocytes more efficiently than either a longer persisting DeltaaroD Salmonella typhimurium strain SL7207 or transiently persistent S. typhi strain Ty21a harboring DNA vaccines. Also, the frequency of antigen-specific gamma interferon (IFN-gamma) producing cells induced by Shigella 15D harboring a DNA vaccine were comparable to that induced by intramuscular (i.m.) immunization with purified DNA vaccine. Moreover, the magnitude of mucosal and systemic antigen-specific IgA and IgG responses after immunization were dependent upon the route (i.m. vs. i.n.) of inoculation, with i.n. Shigella 15D DNA vaccines generating higher levels of HIV-specific IgA in vaginal washings than i.m. purified DNA vaccine. Deltaasd S. flexneri is a promising vector for mucosal DNA vaccine immunization against HIV.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AIDS Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, nef,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Attenuated,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA,
http://linkedlifedata.com/resource/pubmed/chemical/nef Gene Products, Human...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
0165-2478
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
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| pubmed:volume |
82
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
197-204
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12036602-AIDS Vaccines,
pubmed-meshheading:12036602-Administration, Intranasal,
pubmed-meshheading:12036602-Animals,
pubmed-meshheading:12036602-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12036602-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12036602-Female,
pubmed-meshheading:12036602-Gene Products, nef,
pubmed-meshheading:12036602-HIV,
pubmed-meshheading:12036602-HIV Envelope Protein gp120,
pubmed-meshheading:12036602-Mice,
pubmed-meshheading:12036602-Mice, Inbred C57BL,
pubmed-meshheading:12036602-Nasal Mucosa,
pubmed-meshheading:12036602-Salmonella,
pubmed-meshheading:12036602-Shigella,
pubmed-meshheading:12036602-Simian immunodeficiency virus,
pubmed-meshheading:12036602-Vaccines, Attenuated,
pubmed-meshheading:12036602-Vaccines, DNA,
pubmed-meshheading:12036602-nef Gene Products, Human Immunodeficiency Virus
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| pubmed:year |
2002
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| pubmed:articleTitle |
Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV.
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| pubmed:affiliation |
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|