Source:http://linkedlifedata.com/resource/pubmed/id/12036441
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2002-5-30
|
| pubmed:abstractText |
Several studies have reported a higher prevalence of chronic hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin's lymphoma and suggested a pathogenic role for HCV, but studies on hepatitis B virus (HBV) infection and non-Hodgkin's lymphoma are limited. To determine the association between HBV infection and non-Hodgkin's lymphoma, we performed a case-control study in Korea, a hepatitis B endemic area. We recruited 222 patients newly diagnosed with non-Hodgkin's lymphoma at Seoul National University Hospital between January 1997 and December 1998 as cases. Four age- and sex-matched controls were selected for each case, and the control groups comprised of 439 patients with non-hematological malignancy (control group 1) and 444 subjects with non-malignant conditions (control group 2). Relative risk of developing non-Hodgkin's lymphoma among individuals tested positive for hepatitis B surface antigen was calculated after controlling for other potential risk factors of lymphoma, such as smoking, alcohol drinking, transfusion history and HCV infection. Hepatitis B surface antigen was positive in 28 of 222 patients (12.6%) with non-Hodgkin's lymphoma compared with 32 of 439 (7.3%) in control group 1, and 21 of 444 (4.7%) in control group 2 (P = 0.001). The crude odds ratio for B-cell non-Hodgkin's lymphoma among the HBV carriers was 2.54 (1.46 - 4.45) and the adjusted odds ratio was 3.30 (1.69 - 6.45) by multivariate analysis. The present study suggests that the risk of B-cell non-Hodgkin's lymphoma is increased in HBV carriers and warrants further investigation of the possible role of hepatitis B virus in the pathogenesis of B-cell non-Hodgkin's lymphoma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0910-5050
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
471-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12036441-Adolescent,
pubmed-meshheading:12036441-Adult,
pubmed-meshheading:12036441-Age Factors,
pubmed-meshheading:12036441-Aged,
pubmed-meshheading:12036441-Aged, 80 and over,
pubmed-meshheading:12036441-Alcohol Drinking,
pubmed-meshheading:12036441-Case-Control Studies,
pubmed-meshheading:12036441-Female,
pubmed-meshheading:12036441-Hepatitis B,
pubmed-meshheading:12036441-Hepatitis B virus,
pubmed-meshheading:12036441-Humans,
pubmed-meshheading:12036441-Korea,
pubmed-meshheading:12036441-Lymphoma, B-Cell,
pubmed-meshheading:12036441-Male,
pubmed-meshheading:12036441-Middle Aged,
pubmed-meshheading:12036441-Models, Statistical,
pubmed-meshheading:12036441-Multivariate Analysis,
pubmed-meshheading:12036441-Odds Ratio,
pubmed-meshheading:12036441-Risk,
pubmed-meshheading:12036441-Smoking
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Hepatitis B virus infection and B-cell non-Hodgkin's lymphoma in a hepatitis B endemic area: a case-control study.
|
| pubmed:affiliation |
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, South Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|