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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-5-30
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pubmed:abstractText |
As an extension of structure/activity investigations of resveratrol (1), phenstatin (2c), and the cancer antiangiogenesis drug sodium combretastatin A-4 phosphate (2b), syntheses of certain related stilbenes (14) and benzophenones (16) were undertaken. The trimethyl ether derivative of (Z)-resveratrol (4a) exhibited the strongest activity (GI(50) = 0.01-0.001 microg/mL) against a minipanel of human cancer cell lines. A monodemethylated derivative (14c) was converted to prodrug 14n (sodium resverastatin phosphate) for further biological evaluation. The antitubulin and antimicrobial activities of selected compounds were also evaluated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2534-42
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12036362-Anti-Bacterial Agents,
pubmed-meshheading:12036362-Anti-Infective Agents,
pubmed-meshheading:12036362-Antineoplastic Agents,
pubmed-meshheading:12036362-Bacteria,
pubmed-meshheading:12036362-Biopolymers,
pubmed-meshheading:12036362-Cell Division,
pubmed-meshheading:12036362-Drug Screening Assays, Antitumor,
pubmed-meshheading:12036362-Fungi,
pubmed-meshheading:12036362-Humans,
pubmed-meshheading:12036362-Microbial Sensitivity Tests,
pubmed-meshheading:12036362-Phosphoric Acid Esters,
pubmed-meshheading:12036362-Prodrugs,
pubmed-meshheading:12036362-Stereoisomerism,
pubmed-meshheading:12036362-Stilbenes,
pubmed-meshheading:12036362-Structure-Activity Relationship,
pubmed-meshheading:12036362-Tubulin,
pubmed-meshheading:12036362-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate.
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pubmed:affiliation |
Department of Chemistry and Biochemistry, Cancer Research Institute, Arizona State University, P.O. Box 872404, Tempe, AZ 85287-2404, USA. bpettit@asu.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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