| pubmed-article:12032301 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12032301 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:12032301 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:12032301 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:12032301 | lifeskim:mentions | umls-concept:C0919532 | lld:lifeskim |
| pubmed-article:12032301 | lifeskim:mentions | umls-concept:C0033713 | lld:lifeskim |
| pubmed-article:12032301 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:12032301 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:12032301 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12032301 | pubmed:dateCreated | 2002-5-28 | lld:pubmed |
| pubmed-article:12032301 | pubmed:abstractText | Vertebrates have three related Myb genes. The c-Myb protooncogene is required for definitive hematopoiesis in mice and when mutated causes leukemias and lymphomas in birds and mammals. The A-Myb gene is required for spermatogenesis and mammary gland proliferation in mice. The ubiquitously expressed B-Myb gene is essential for early embryonic development in mice and is directly regulated by the p16/cyclin D/Rb family/E2F pathway along with many critical S-phase genes. Drosophila has a single Myb gene most closely related to B-Myb. We have isolated two late-larval lethal alleles of Drosophila Myb. Mutant imaginal discs show an increased number of cells arrested in M phase. Mutant mitotic cells display a variety of abnormalities including spindle defects and increased polyploidy and aneuploidy. Remarkably, some mutant cells have an aberrant S- to M-phase transition in which replicating chromosomes undergo premature histone phosphorylation and chromosomal condensation. These results suggest that the absence of Drosophila Myb causes a defect in S phase that may result in M-phase abnormalities. Consistent with a role for Drosophila Myb during S phase, we detected Dm-Myb protein in S-phase nuclei of wild-type mitotic cells as well as endocycling cells, which lack both an M phase and cyclin B expression. Moreover, we found that the Dm-Myb protein is concentrated in regions of S-phase nuclei that are actively undergoing DNA replication. Together these findings imply that Dm-Myb provides an essential nontranscriptional function during chromosomal replication. | lld:pubmed |
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| pubmed-article:12032301 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12032301 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12032301 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12032301 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12032301 | pubmed:month | May | lld:pubmed |
| pubmed-article:12032301 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12032301 | pubmed:author | pubmed-author:LipsickJoseph... | lld:pubmed |
| pubmed-article:12032301 | pubmed:author | pubmed-author:ManakJ... | lld:pubmed |
| pubmed-article:12032301 | pubmed:author | pubmed-author:MitikuNesanet... | lld:pubmed |
| pubmed-article:12032301 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12032301 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:12032301 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:12032301 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12032301 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12032301 | pubmed:pagination | 7438-43 | lld:pubmed |
| pubmed-article:12032301 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12032301 | pubmed:meshHeading | pubmed-meshheading:12032301... | lld:pubmed |
| pubmed-article:12032301 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12032301 | pubmed:articleTitle | Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability. | lld:pubmed |
| pubmed-article:12032301 | pubmed:affiliation | Department of Pathology, Stanford University School of Medicine, Room L216, 300 Pasteur Drive, Stanford, CA 94305-5324, USA. | lld:pubmed |
| pubmed-article:12032301 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12032301 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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