Source:http://linkedlifedata.com/resource/pubmed/id/12031338
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2002-5-28
|
| pubmed:abstractText |
Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and D-seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1543-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12031338-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:12031338-Drug Resistance, Neoplasm,
pubmed-meshheading:12031338-Inhibitory Concentration 50,
pubmed-meshheading:12031338-Paclitaxel,
pubmed-meshheading:12031338-Structure-Activity Relationship,
pubmed-meshheading:12031338-Taxoids,
pubmed-meshheading:12031338-Tumor Cells, Cultured
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Synthesis and cytotoxicity of 2alpha-amido docetaxel analogues.
|
| pubmed:affiliation |
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, PR China. wfang@imm.ac.cn
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|