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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2002-5-28
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pubmed:abstractText |
Given the proposed involvement of VLA-4 in inflammatory processes, a program to identify orally active VLA-4 antagonists was initiated. Herein, we report the discovery of a N-tetrahydrofuroyl-(L)-phenylalanine derivative (17) and related analogues as potent VLA-4 antagonists with good oral bioavailability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ChangLinda LLL,
pubmed-author:DohertyGeorge AGA,
pubmed-author:EggerLinda ALA,
pubmed-author:HagmannWilliam KWK,
pubmed-author:KidambiUshaU,
pubmed-author:LiBingB,
pubmed-author:MacCossMalcolmM,
pubmed-author:MagriotisPlato APA,
pubmed-author:McCauleyErmengildaE,
pubmed-author:MumfordRichard ARA,
pubmed-author:SchmidtJohn AJA,
pubmed-author:TruongQuangQ,
pubmed-author:Van RiperGailG,
pubmed-author:YangGinger XGX,
pubmed-author:de LaszloStephen ESE
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1497-500
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12031328-Administration, Oral,
pubmed-meshheading:12031328-Animals,
pubmed-meshheading:12031328-Binding Sites,
pubmed-meshheading:12031328-Biological Availability,
pubmed-meshheading:12031328-Dose-Response Relationship, Drug,
pubmed-meshheading:12031328-Furans,
pubmed-meshheading:12031328-Half-Life,
pubmed-meshheading:12031328-Inhibitory Concentration 50,
pubmed-meshheading:12031328-Integrin alpha4beta1,
pubmed-meshheading:12031328-Macaca mulatta,
pubmed-meshheading:12031328-Phenylalanine,
pubmed-meshheading:12031328-Rats,
pubmed-meshheading:12031328-Rats, Sprague-Dawley,
pubmed-meshheading:12031328-Structure-Activity Relationship,
pubmed-meshheading:12031328-Sulfonamides,
pubmed-meshheading:12031328-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2002
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pubmed:articleTitle |
N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. ginger_yang@merck.com
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pubmed:publicationType |
Journal Article,
Comparative Study
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