| pubmed-article:12024021 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12024021 | lifeskim:mentions | umls-concept:C0120465 | lld:lifeskim |
| pubmed-article:12024021 | lifeskim:mentions | umls-concept:C0379310 | lld:lifeskim |
| pubmed-article:12024021 | lifeskim:mentions | umls-concept:C1120843 | lld:lifeskim |
| pubmed-article:12024021 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:12024021 | lifeskim:mentions | umls-concept:C0812248 | lld:lifeskim |
| pubmed-article:12024021 | lifeskim:mentions | umls-concept:C1155502 | lld:lifeskim |
| pubmed-article:12024021 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12024021 | pubmed:dateCreated | 2002-5-23 | lld:pubmed |
| pubmed-article:12024021 | pubmed:abstractText | Tiam1 and Ras-GRF1 are guanine nucleotide exchange factors (GEFs) that activate the Rac GTPase. The two GEFs have similar N-terminal regions containing pleckstrin homology domains followed by coiled-coils and additional sequences that function together to allow regulated GEF activity. Here we show that this N-terminal region of both proteins binds to the scaffold protein IB2/JIP2. IB2/JIP2 is a scaffold for the p38 mitogen-activated protein (MAP) kinase cascade because it binds to the Rac target MLK3, the MAP kinase kinase MKK3, and the p38 MAP kinase. Expression of IB2/JIP2 in cells potentiates the ability of Tiam1 or Ras-GRF1 to activate the p38 MAP kinase cascade but not the Jnk MAP kinase cascade. In addition, Tiam1 or Ras-GRF1 binding to IB2/JIP2 increases the association of the components of the p38 MAP kinase signaling cassette with IB2/JIP2 in cells and activates scaffold-associated p38. These findings imply that Tiam1 and Ras-GRF1 can contribute to Rac signaling specificity by their ability to form a complex with a scaffold that binds components of one of the many known Rac effector pathways. | lld:pubmed |
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| pubmed-article:12024021 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12024021 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12024021 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12024021 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12024021 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12024021 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:12024021 | pubmed:author | pubmed-author:FeigLarry ALA | lld:pubmed |
| pubmed-article:12024021 | pubmed:author | pubmed-author:BuchsbaumRach... | lld:pubmed |
| pubmed-article:12024021 | pubmed:author | pubmed-author:ConnollyBeth... | lld:pubmed |
| pubmed-article:12024021 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12024021 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12024021 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12024021 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12024021 | pubmed:pagination | 4073-85 | lld:pubmed |
| pubmed-article:12024021 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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