Source:http://linkedlifedata.com/resource/pubmed/id/12022701
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2002-5-22
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pubmed:abstractText |
Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of the hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in broncho-constriction, lung damage and, ultimately, fibrosis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate that activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0004-069X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-30
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12022701-Asthma,
pubmed-meshheading:12022701-Cell Survival,
pubmed-meshheading:12022701-Eosinophils,
pubmed-meshheading:12022701-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:12022701-Humans,
pubmed-meshheading:12022701-RNA, Messenger,
pubmed-meshheading:12022701-RNA Processing, Post-Transcriptional,
pubmed-meshheading:12022701-RNA Stability,
pubmed-meshheading:12022701-Signal Transduction
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pubmed:year |
2002
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pubmed:articleTitle |
GM-CSF regulation in eosinophils.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison 53792, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review
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