Linked Life Data

12022418

Source:http://linkedlifedata.com/resource/pubmed/id/12022418

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-5-22
pubmed:abstractText
The wear, wear debris and functional biological activity of non-crosslinked and moderately crosslinked ultrahigh molecular weight polyethylene (UHMWPE) acetabular cups have been com pared when articulating against smooth and intentionally scratched femoral heads. Volumetric wear rates were determined in a hip joint simulator and the debris was isolated from the lubricant and characterized by the percentage number and volumetric concentration as a function of particle size. The volumetric concentration was integrated with the biological activity function determined from in vitro cell culture studies to predict an index of specific biological activity (SBA). The product of specific biological activity and volumetric wear rate was used to determine the index of functional biological activity (FBA). On smooth femoral heads the crosslinked UHMWPE had a 30 per cent lower wear rate, but it had a greater percentage volume of smaller, more biologically active particles, which resulted in a similar index of FBA compared with the non-crosslinked material. On the scratched femoral heads the volumetric wear rate was three times higher for the moderately crosslinked UHMWPE and two times higher for the non-crosslinked UHMWPE compared with the smooth femoral heads. This resulted in a higher wear rate for the moderately crosslinked material on the scratched femoral heads. All the differences in wear rate were statistically significant. There were only small differences in particle volume concentration distributions, and this resulted in similar indices of FBA which were approximately twice the values of those found on the smooth femoral heads. Both materials showed lower wear and FBA than for previously studied aged and oxidized UHMWPE gamma irradiated in air. However, this study did not reveal any advantage in terms of predicted FBA for moderately crosslinked UHMWPE compared with non-crosslinked UHMWPE.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0954-4119
pubmed:author
pubmed:issnType
Print
pubmed:volume
216
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-22
pubmed:dateRevised
2009-6-8
pubmed:meshHeading
pubmed-meshheading:12022418-Acetylene, pubmed-meshheading:12022418-Chromium Alloys, pubmed-meshheading:12022418-Cobalt, pubmed-meshheading:12022418-Cross-Linking Reagents, pubmed-meshheading:12022418-Equipment Failure Analysis, pubmed-meshheading:12022418-Ethylene Oxide, pubmed-meshheading:12022418-Femur Head, pubmed-meshheading:12022418-Friction, pubmed-meshheading:12022418-Hip Prosthesis, pubmed-meshheading:12022418-Humans, pubmed-meshheading:12022418-Materials Testing, pubmed-meshheading:12022418-Models, Biological, pubmed-meshheading:12022418-Motion, pubmed-meshheading:12022418-Polyethylenes, pubmed-meshheading:12022418-Prosthesis Failure, pubmed-meshheading:12022418-Quantitative Structure-Activity Relationship, pubmed-meshheading:12022418-Range of Motion, Articular, pubmed-meshheading:12022418-Surface Properties, pubmed-meshheading:12022418-Weight-Bearing
pubmed:year
2002
pubmed:articleTitle
Comparison of wear, wear debris and functional biological activity of moderately crosslinked and non-crosslinked polyethylenes in hip prostheses.
pubmed:affiliation
Medical and Biological Engineering, University of Leeds, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't