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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2002-5-21
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pubmed:abstractText |
Human herpesvirus 6 (HHV-6), a latent lymphotropic and neurotropic virus, has been suspected as an etiologic agent in multiple sclerosis (MS). The study was undertaken to correlate virologic evidence for HHV-6 activity with the state of host immunity to HHV-6 in MS patients and control subjects. The study revealed that cell-free DNA of HHV-6 was detected more frequently in both serum and cerebrospinal fluid of MS patients than in those of control subjects. T cells recognizing the recombinant 101-kDa protein (101K) corresponding to the major immunoreactive region unique to HHV-6 occurred at significantly lower precursor frequency in MS patients than in control subjects. The resulting HHV-6-specific T-cell lines obtained from MS patients exhibited skewed cytokine profiles characterized by the inability to produce interleukin-4 (IL-4) and IL-10. The decreased T-cell responses to HHV-6 and the altered cytokine profile were consistent with significantly declined serum immunoglobulin G (IgG) titers for HHV-6 of MS patients compared to those of control subjects. In contrast, elevated serum IgM titers for HHV-6 were detected in the majority of MS patients, which may reflect frequent exposure of B cells to HHV-6. The findings suggest that the decreased immune responses to HHV-6 may be responsible for ineffective clearance of HHV-6 in MS patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-10321977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-10391860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-10487765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-10716249,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-10908883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-10908887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-11023456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-11049767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-11099303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-11395137,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-2550877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-2876520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-2926166,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-9396611,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12021348-9987758
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6147-54
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12021348-Amino Acid Sequence,
pubmed-meshheading:12021348-Antibodies, Viral,
pubmed-meshheading:12021348-DNA, Viral,
pubmed-meshheading:12021348-Herpesviridae Infections,
pubmed-meshheading:12021348-Herpesvirus 6, Human,
pubmed-meshheading:12021348-Humans,
pubmed-meshheading:12021348-Molecular Sequence Data,
pubmed-meshheading:12021348-Multiple Sclerosis,
pubmed-meshheading:12021348-T-Lymphocytes,
pubmed-meshheading:12021348-Viral Proteins,
pubmed-meshheading:12021348-Virion
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pubmed:year |
2002
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pubmed:articleTitle |
Detection of viral DNA and immune responses to the human herpesvirus 6 101-kilodalton virion protein in patients with multiple sclerosis and in controls.
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pubmed:affiliation |
Multiple Sclerosis Research Unit, Department of Neurology and Baylor-Methodist Multiple Sclerosis Center, Baylor College of Medicine, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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