Linked Life Data

12021306

Source:http://linkedlifedata.com/resource/pubmed/id/12021306

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2002-5-21
pubmed:abstractText
Various immune diseases are considered to be regulated by the balance of T helper (Th)1 and Th2 subsets. Although Th lymphocytes are believed to be generated in draining lymph nodes (LNs), in vivo Th cell behaviors during Th1/Th2 polarization are largely unexplored. Using a murine granulomatous liver disease model induced by Propionibacterium acnes, we show that retention of Th1 cells in the LNs is controlled by a chemokine, CXCL10/interferon (IFN) inducible protein 10 produced by mature dendritic cells (DCs). Hepatic LN DCs preferentially produced CXCL10 to attract 5'-bromo-2'-deoxyuridine (BrdU)+CD4+ T cells and form clusters with IFN-gamma-producing CD4+ T cells by day 7 after antigen challenge. Blockade of CXCL10 dramatically altered the distribution of cluster-forming BrdU+CD4+ T cells. BrdU+CD4+ T cells in the hepatic LNs were selectively diminished while those in the circulation were significantly increased by treatment with anti-CXCL10 monoclonal antibody. This was accompanied by accelerated infiltration of memory T cells into the periphery of hepatic granuloma sites, most of them were in cell cycle and further produced higher amount of IFN-gamma leading to exacerbation of liver injury. Thus, mature DC-derived CXCL10 is pivotal to retain Th1 lymphocytes within T cell areas of draining LNs and optimize the Th1-mediated immune responses.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10221917, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10359116, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10408488, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10419874, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10520991, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10591648, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10617422, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10805209, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10843381, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10880246, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10946253, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-10998315, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11017102, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11021530, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11021806, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11034600, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11085753, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11104797, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11136819, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11155440, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11160258, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11175801, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11242050, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11304558, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11304560, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11525941, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11673480, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-11782014, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-1640172, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-7879916, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-8600538, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-8962631, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-9034155, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-9182685, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-9521319, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-9651253, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-9790904, http://linkedlifedata.com/resource/pubmed/commentcorrection/12021306-9835618
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Ccl21c protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Ccl22 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL21, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL22, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL10, http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC, http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC, http://linkedlifedata.com/resource/pubmed/chemical/Cxcr3 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
195
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1257-66
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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