Linked Life Data

12020964

Source:http://linkedlifedata.com/resource/pubmed/id/12020964

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2002-5-21
pubmed:abstractText
Microchimerism (MC) is the stable presence of small numbers of non-host cells and appears to be commonly present in parous women. There are several methods of detecting microchimerism and each has advantages for different types of studies, but the risk of contamination and the differing levels of sensitivity lead to difficulties in estimating the proportion of individuals that are microchimeric. Recent observations of an increased frequency of microchimerism in women with scleroderma and Hashimoto's thyroiditis suggest that microchimerism may increase the risk of developing autoimmune disease. Inferences regarding autoimmunity are drawn from the immunological effects of organ and bone-marrow transplantation. Potential research questions regarding microchimerism, human leukocyte antigen (HLA) similarity, and autoimmune diseases in the context of multiple sclerosis (MS) are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0165-5728
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
126-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Microchimerism in autoimmunity and transplantation: potential relevance to multiple sclerosis.
pubmed:affiliation
Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't