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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1976-3-1
|
| pubmed:abstractText |
The chemically modified polyene macrolide antibiotic, amphotericin B methyl ester (AME), exhibited a concentration-dependent growth stimulatory effect on established lines of mouse (L-M) and monkey (Vero) cells. Stimulation was indicated by increases in growth rate, and in the enhanced synthesis of DNA and RNA. In contrast, the parental antibiotic amphotericin B and the desoxycholate complex of amphotericin B, FungizoneR, did not elicit a similar proliferative response in L-M or Vero cells. AME was not growth-promoting toward low passage strains of mouse (PMK 6) and monkey cells (MGK 8).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
896-902
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:1201972-Amphotericin B,
pubmed-meshheading:1201972-Cell Division,
pubmed-meshheading:1201972-Cell Line,
pubmed-meshheading:1201972-Cell Survival,
pubmed-meshheading:1201972-DNA,
pubmed-meshheading:1201972-Dose-Response Relationship, Drug,
pubmed-meshheading:1201972-RNA,
pubmed-meshheading:1201972-Stimulation, Chemical
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Stimulatory effect of amphotericin B methyl ester on the grwoth of L-M and Vero cells.
|
| pubmed:publicationType |
Journal Article
|