| pubmed-article:12016893 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12016893 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12016893 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12016893 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:12016893 | lifeskim:mentions | umls-concept:C0248868 | lld:lifeskim |
| pubmed-article:12016893 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:12016893 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12016893 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:12016893 | lifeskim:mentions | umls-concept:C1519355 | lld:lifeskim |
| pubmed-article:12016893 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12016893 | pubmed:dateCreated | 2002-5-17 | lld:pubmed |
| pubmed-article:12016893 | pubmed:abstractText | The relation between Ca2+/CaM PK II activity and excitatoxicity was studied in an in vitro model of rat hippocampal slices. The slices were exposed to 50-200 mumol.L-1 glutamate or 25-100 mumol.L-1 NMDA and glucose-free Krebs buffer for 30 min after being recovered to normal conditions by 2 hours of incubation with standard Krebs buffer. The results showed that inhibition of Ca2+/CaM PK II activity in rat hippocampal slices was induced by exogenous EAA (glutamate or NMDA), and Ca2+/CaM PK II activity values decreased to 50.1% and 44.7% of control at 200 mumol.L-1 glutamate and 100 mumol.L-1 NMDA, respectively; MK801, but not DNQX, antagonized EAA-induced inhibition of Ca2+/CaM PK II activity. When the slices were pretreated with MK801 prior to exposure to 200 mumol.L-1 glutamate or 100 mumol.L-1 NMDA, the Ca2+/Cam PK II activity values were 91.5% and 96.7%, respectively. The changes of extracellular Ca2+ or Mg2+ concentration influenced Ca2+/CaM PK II activity of the slices exposed to exogenous glutamate; Ca2+/CaM PK II activity values in the presence of extracellular Ca2+ was lower than that in the absence of extracellular Ca2+, and it changed from 50.1% of control (presence of Ca2+) to 64% of control (absence of Ca2+) at 200 mumol.L-1 glutamate, but Ca2+/CaM PK II activity values in the presence of extracellular Mg2+ was higher than that in the absence of extracellular Mg2+, and it changed from 50.1% of control(presence of Mg2+) to 36.6% of control (absence of Mg2+) at 200 mumol.L-1 glutamate. The results suggest that NMDA receptor may be involved in excitotoxicity-induced inhibition of Ca2+/CaM PK II activity. | lld:pubmed |
| pubmed-article:12016893 | pubmed:language | chi | lld:pubmed |
| pubmed-article:12016893 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12016893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12016893 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12016893 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12016893 | pubmed:issn | 0513-4870 | lld:pubmed |
| pubmed-article:12016893 | pubmed:author | pubmed-author:ZoniGG | lld:pubmed |
| pubmed-article:12016893 | pubmed:author | pubmed-author:ZhangGG | lld:pubmed |
| pubmed-article:12016893 | pubmed:author | pubmed-author:FengXX | lld:pubmed |
| pubmed-article:12016893 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12016893 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:12016893 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12016893 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12016893 | pubmed:pagination | 561-5 | lld:pubmed |
| pubmed-article:12016893 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:12016893 | pubmed:meshHeading | pubmed-meshheading:12016893... | lld:pubmed |
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| pubmed-article:12016893 | pubmed:meshHeading | pubmed-meshheading:12016893... | lld:pubmed |
| pubmed-article:12016893 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:12016893 | pubmed:articleTitle | [Effect of excitatoxicity on Ca2+/CaM PK II activity in rat hippocampal slices]. | lld:pubmed |
| pubmed-article:12016893 | pubmed:affiliation | Research Center of Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002. | lld:pubmed |
| pubmed-article:12016893 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12016893 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12016893 | pubmed:publicationType | English Abstract | lld:pubmed |
| pubmed-article:12016893 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
