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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5571
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pubmed:dateCreated |
2002-5-17
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pubmed:abstractText |
RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Double-Stranded,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Untranslated,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
296
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1319-21
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12016316-Agrobacterium tumefaciens,
pubmed-meshheading:12016316-Animals,
pubmed-meshheading:12016316-Cell Line,
pubmed-meshheading:12016316-Drosophila,
pubmed-meshheading:12016316-Gene Silencing,
pubmed-meshheading:12016316-Genes, Viral,
pubmed-meshheading:12016316-Green Fluorescent Proteins,
pubmed-meshheading:12016316-Luminescent Proteins,
pubmed-meshheading:12016316-Nodaviridae,
pubmed-meshheading:12016316-Plant Leaves,
pubmed-meshheading:12016316-Plants, Genetically Modified,
pubmed-meshheading:12016316-RNA, Double-Stranded,
pubmed-meshheading:12016316-RNA, Small Interfering,
pubmed-meshheading:12016316-RNA, Untranslated,
pubmed-meshheading:12016316-RNA, Viral,
pubmed-meshheading:12016316-Tobacco,
pubmed-meshheading:12016316-Transfection,
pubmed-meshheading:12016316-Viral Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Induction and suppression of RNA silencing by an animal virus.
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pubmed:affiliation |
Department of Plant Pathology and Center for Plant Cell Biology, University of California, Riverside, CA 92521, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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