Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5575
pubmed:dateCreated
2002-6-14
pubmed:abstractText
Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
296
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2046-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:12016205-Amino Acid Sequence, pubmed-meshheading:12016205-Animals, pubmed-meshheading:12016205-Animals, Newborn, pubmed-meshheading:12016205-Blotting, Northern, pubmed-meshheading:12016205-CHO Cells, pubmed-meshheading:12016205-Capsaicin, pubmed-meshheading:12016205-Cation Transport Proteins, pubmed-meshheading:12016205-Cell Line, pubmed-meshheading:12016205-Cells, Cultured, pubmed-meshheading:12016205-Cloning, Molecular, pubmed-meshheading:12016205-Cricetinae, pubmed-meshheading:12016205-Epidermis, pubmed-meshheading:12016205-Ganglia, Spinal, pubmed-meshheading:12016205-Hot Temperature, pubmed-meshheading:12016205-Humans, pubmed-meshheading:12016205-In Situ Hybridization, pubmed-meshheading:12016205-Ion Channels, pubmed-meshheading:12016205-Keratinocytes, pubmed-meshheading:12016205-Membrane Potentials, pubmed-meshheading:12016205-Mice, pubmed-meshheading:12016205-Molecular Sequence Data, pubmed-meshheading:12016205-Nerve Endings, pubmed-meshheading:12016205-Neurons, pubmed-meshheading:12016205-Patch-Clamp Techniques, pubmed-meshheading:12016205-RNA, Messenger, pubmed-meshheading:12016205-Ruthenium Red, pubmed-meshheading:12016205-Signal Transduction, pubmed-meshheading:12016205-Spinal Cord, pubmed-meshheading:12016205-TRPV Cation Channels, pubmed-meshheading:12016205-Temperature
pubmed:year
2002
pubmed:articleTitle
A heat-sensitive TRP channel expressed in keratinocytes.
pubmed:affiliation
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't