Source:http://linkedlifedata.com/resource/pubmed/id/12015602
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6886
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| pubmed:dateCreated |
2002-5-16
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| pubmed:abstractText |
Pavlovian conditioning results when an innocuous stimulus, such as an odour, is paired with a behaviourally relevant stimulus, such as a foot-shock, so that eventually the former stimulus alone will elicit the behavioural response of the latter. The lateral nucleus of the amygdala (LAT) is necessary for the emotional memory formation in this paradigm. Enhanced neuronal firing in LAT to conditioned stimuli emerge in parallel with the behavioural changes and are dependent on local dopamine. To study the changes in neuronal excitability and synaptic drive that contribute to the pavlovian conditioning process, here we used in vivo intracellular recordings to examine LAT neurons during pavlovian conditioning in rats. We found that repeated pairings of an odour with a foot-shock resulted in enhanced post-synaptic potential (PSP) responses to the odour and increased neuronal excitability. However, a non-paired odour displayed PSP decrement. The dopamine antagonist haloperidol blocked the PSP enhancement and associated increased neuronal excitability, without reversing previous conditioning. These results demonstrate that conditioning and habituation processes produce opposite effects on LAT neurons and that dopamine is important in these events, consistent with its role in emotional memory formation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0028-0836
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
16
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| pubmed:volume |
417
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
282-7
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12015602-Amygdala,
pubmed-meshheading:12015602-Analysis of Variance,
pubmed-meshheading:12015602-Anesthesia,
pubmed-meshheading:12015602-Animals,
pubmed-meshheading:12015602-Conditioning, Classical,
pubmed-meshheading:12015602-Dopamine,
pubmed-meshheading:12015602-Dopamine Antagonists,
pubmed-meshheading:12015602-Electroshock,
pubmed-meshheading:12015602-Evoked Potentials, Somatosensory,
pubmed-meshheading:12015602-Excitatory Postsynaptic Potentials,
pubmed-meshheading:12015602-Haloperidol,
pubmed-meshheading:12015602-Male,
pubmed-meshheading:12015602-Memory,
pubmed-meshheading:12015602-Neurons,
pubmed-meshheading:12015602-Odors,
pubmed-meshheading:12015602-Rats,
pubmed-meshheading:12015602-Rats, Sprague-Dawley,
pubmed-meshheading:12015602-Receptors, Dopamine,
pubmed-meshheading:12015602-Smell
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| pubmed:year |
2002
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| pubmed:articleTitle |
Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning.
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| pubmed:affiliation |
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. rosenk@bns.pitt.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|