Linked Life Data

12015205

Source:http://linkedlifedata.com/resource/pubmed/id/12015205

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-5-16
pubmed:abstractText
The hypothalamus is a critical centre for the control of appetite. Neuropeptide Y (NPY) and alpha-melanocyte stimulating hormone (alpha-MSH) exert opposing effects on feeding and substantial neuroanatomical evidence exists to suggest these hypothalamic peptides may interact to alter feeding behaviour. We have examined central interactions between these two peptide systems on food intake in satiated male Sprague-Dawley rats. NPY-induced (1 nmol; i.c.v.) food intake was significantly attenuated by subsequent alpha-MSH administration (1 and 4 nmol; i.c.v.) at 1 h post-injection and persisted for the entire 4 h observation period (P<0.05). Central administration of the selective MC4-R antagonist HS014 (0.5 nmol) significantly increased food intake compared to saline-vehicle (P<0.05). However, co-administration of HS014 (0.5 nmol) and NPY (0.5 and 1 nmol) did not increase feeding compared to either dose of NPY alone. These results taken together provide some evidence for an interaction between these mediators in the control of food intake.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
792-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Evidence for an interaction between neuropeptide Y and the melanocortin-4 receptor on feeding in the rat.
pubmed:affiliation
Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't