| pubmed-article:12015202 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12015202 | lifeskim:mentions | umls-concept:C0028633 | lld:lifeskim |
| pubmed-article:12015202 | lifeskim:mentions | umls-concept:C0031381 | lld:lifeskim |
| pubmed-article:12015202 | lifeskim:mentions | umls-concept:C0282151 | lld:lifeskim |
| pubmed-article:12015202 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12015202 | lifeskim:mentions | umls-concept:C0234402 | lld:lifeskim |
| pubmed-article:12015202 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:12015202 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12015202 | pubmed:dateCreated | 2002-5-16 | lld:pubmed |
| pubmed-article:12015202 | pubmed:abstractText | The effects of microinjection of phencyclidine (PCP) and dizocilpine, non-competitive NMDA receptor antagonists, and dopamine into the nucleus accumbens were examined in rats trained to discriminate PCP (1.5 mg/kg i.p.) from saline under a two-lever fixed ratio 20 schedule of food reinforcement. Microinjection of PCP (2-40 microg) and dizocilpine (2-12 microg) into the bilateral nucleus accumbens produced a dose-dependent increase in PCP-appropriate responding and fully substituted for systemically administered PCP, whereas microinjection of dopamine (1-4 microg) did not produce PCP-like discriminative stimulus effects. The performance of PCP discrimination was assessed after bilateral destruction of the dopaminergic nerve neurons in the nucleus accumbens with dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA, 4 microg/1 microl/side). The destruction of dopaminergic nerve neurons in the nucleus accumbens failed to prevent the performance of PCP discrimination. There was no difference in the average percentages of PCP-appropriate responding between vehicle and 6-OHDA-treated rats in the dose-response tests. These results suggest that the dopaminergic system in the nucleus accumbens does not play a critical role in the discriminative stimulus effects of PCP. | lld:pubmed |
| pubmed-article:12015202 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12015202 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12015202 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12015202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12015202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12015202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12015202 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12015202 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12015202 | pubmed:month | May | lld:pubmed |
| pubmed-article:12015202 | pubmed:issn | 0028-3908 | lld:pubmed |
| pubmed-article:12015202 | pubmed:author | pubmed-author:FurukawaHiros... | lld:pubmed |
| pubmed-article:12015202 | pubmed:author | pubmed-author:NabeshimaTosh... | lld:pubmed |
| pubmed-article:12015202 | pubmed:author | pubmed-author:NodaYukihiroY | lld:pubmed |
| pubmed-article:12015202 | pubmed:author | pubmed-author:MoriAkitomoA | lld:pubmed |
| pubmed-article:12015202 | pubmed:author | pubmed-author:NagaiTakuT | lld:pubmed |
| pubmed-article:12015202 | pubmed:author | pubmed-author:MamiyaTakayos... | lld:pubmed |
| pubmed-article:12015202 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12015202 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:12015202 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12015202 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12015202 | pubmed:pagination | 764-71 | lld:pubmed |
| pubmed-article:12015202 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:meshHeading | pubmed-meshheading:12015202... | lld:pubmed |
| pubmed-article:12015202 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12015202 | pubmed:articleTitle | Involvement of dopaminergic system in the nucleus accumbens in the discriminative stimulus effects of phencyclidine. | lld:pubmed |
| pubmed-article:12015202 | pubmed:affiliation | Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan. | lld:pubmed |
| pubmed-article:12015202 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12015202 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
