Source:http://linkedlifedata.com/resource/pubmed/id/12015202
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2002-5-16
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pubmed:abstractText |
The effects of microinjection of phencyclidine (PCP) and dizocilpine, non-competitive NMDA receptor antagonists, and dopamine into the nucleus accumbens were examined in rats trained to discriminate PCP (1.5 mg/kg i.p.) from saline under a two-lever fixed ratio 20 schedule of food reinforcement. Microinjection of PCP (2-40 microg) and dizocilpine (2-12 microg) into the bilateral nucleus accumbens produced a dose-dependent increase in PCP-appropriate responding and fully substituted for systemically administered PCP, whereas microinjection of dopamine (1-4 microg) did not produce PCP-like discriminative stimulus effects. The performance of PCP discrimination was assessed after bilateral destruction of the dopaminergic nerve neurons in the nucleus accumbens with dopaminergic neurotoxin, 6-hydroxydopamine (6-OHDA, 4 microg/1 microl/side). The destruction of dopaminergic nerve neurons in the nucleus accumbens failed to prevent the performance of PCP discrimination. There was no difference in the average percentages of PCP-appropriate responding between vehicle and 6-OHDA-treated rats in the dose-response tests. These results suggest that the dopaminergic system in the nucleus accumbens does not play a critical role in the discriminative stimulus effects of PCP.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0028-3908
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
764-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12015202-Adrenergic Agents,
pubmed-meshheading:12015202-Animals,
pubmed-meshheading:12015202-Discrimination Learning,
pubmed-meshheading:12015202-Dopamine,
pubmed-meshheading:12015202-Dose-Response Relationship, Drug,
pubmed-meshheading:12015202-Excitatory Amino Acid Antagonists,
pubmed-meshheading:12015202-Male,
pubmed-meshheading:12015202-Nucleus Accumbens,
pubmed-meshheading:12015202-Oxidopamine,
pubmed-meshheading:12015202-Phencyclidine,
pubmed-meshheading:12015202-Rats,
pubmed-meshheading:12015202-Rats, Inbred F344,
pubmed-meshheading:12015202-Reaction Time
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pubmed:year |
2002
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pubmed:articleTitle |
Involvement of dopaminergic system in the nucleus accumbens in the discriminative stimulus effects of phencyclidine.
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pubmed:affiliation |
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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