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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1976-3-1
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pubmed:abstractText |
The pharmacological activity of two natural bombesin-like peptides, alytesin and litorin, and 25 related synthetic peptides has been compared to that of bombesin. 2 The minimum length of the amino acid chain required for the first appearance of bombesin-like effects was represented by the C-terminal heptapeptide, and the minimum length for maximal effects by the C-terminal nonapeptide. The latter possessed approximately the same activity as bombesin and may be considered a good substitute. 3 Both the tryptophan and histidine residues seemed to be essential for bombesin-like activity. 4 The C-terminal octapeptide was less active than either bombesin or the C-terminal nonapeptide and its action was more rapid in onset and less sustained. 5 Litorin apparently has an intermediate position between bombesin octapeptide and bombesin nonapeptide in the speed and duration of its effects. The relationship between structure and activity is discussed.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
221-7
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1201380-Animals,
pubmed-meshheading:1201380-Blood Pressure,
pubmed-meshheading:1201380-Bombesin,
pubmed-meshheading:1201380-Cats,
pubmed-meshheading:1201380-Dogs,
pubmed-meshheading:1201380-Female,
pubmed-meshheading:1201380-Gallbladder,
pubmed-meshheading:1201380-Gastric Juice,
pubmed-meshheading:1201380-Gastric Mucosa,
pubmed-meshheading:1201380-Gastrins,
pubmed-meshheading:1201380-Intestines,
pubmed-meshheading:1201380-Muscle, Smooth,
pubmed-meshheading:1201380-Muscle Contraction,
pubmed-meshheading:1201380-Oligopeptides,
pubmed-meshheading:1201380-Peptides,
pubmed-meshheading:1201380-Rats,
pubmed-meshheading:1201380-Structure-Activity Relationship,
pubmed-meshheading:1201380-Time Factors,
pubmed-meshheading:1201380-Urinary Bladder,
pubmed-meshheading:1201380-Uterine Contraction
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pubmed:year |
1975
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pubmed:articleTitle |
Relative potency of bombesin-like peptides.
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pubmed:publicationType |
Journal Article,
In Vitro
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