Source:http://linkedlifedata.com/resource/pubmed/id/12011702
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
399
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pubmed:dateCreated |
2002-5-15
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pubmed:abstractText |
Localization and expression of cartilage-derived morphogenetic protein-1 in tissues of torn rotator cuff tendons were examined by in situ hybridization and immunohistochemical analysis. Histologic findings of torn rotator cuff tendons showed that active cells synthesizing the alpha-1 chain of collagen Type I messenger ribonucleic acid were localized predominantly in the torn edge and in the bursa side rather than in the joint side, and scarcely localized in a site distant from the torn edge. Cartilage-derived morphogenetic protein-1 had a similar distribution as the alpha-1 chain of collagen Type I. The current findings provide the first observational evidence that cartilage-derived morphogenetic protein-1 was activated specifically at the site of the torn rotator cuff tendon. The current findings suggest that the cells in the torn rotator cuffs are capable of synthesizing cartilage-derived morphogenetic protein-1, one of the known essential factors for tendon formation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Differentiation Factor 5,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-921X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
140-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12011702-Aged,
pubmed-meshheading:12011702-Bone Morphogenetic Proteins,
pubmed-meshheading:12011702-Collagen Type I,
pubmed-meshheading:12011702-Culture Techniques,
pubmed-meshheading:12011702-Female,
pubmed-meshheading:12011702-Growth Differentiation Factor 5,
pubmed-meshheading:12011702-Growth Substances,
pubmed-meshheading:12011702-Humans,
pubmed-meshheading:12011702-Immunohistochemistry,
pubmed-meshheading:12011702-In Situ Hybridization,
pubmed-meshheading:12011702-Male,
pubmed-meshheading:12011702-Middle Aged,
pubmed-meshheading:12011702-Regeneration,
pubmed-meshheading:12011702-Rotator Cuff,
pubmed-meshheading:12011702-Sensitivity and Specificity
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pubmed:year |
2002
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pubmed:articleTitle |
Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff.
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pubmed:affiliation |
Department of Orthopaedic Surgery, Osaka University Medical School, 2-2 Yamadaoka, Suita 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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