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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-5-15
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pubmed:abstractText |
If T cells require specific interactions with MHC-bound peptides during positive selection, then the specificities of T cells selected by one peptide should be distinct from those selected by another. We have examined positive selection of CD4 T cells in four strains of mice, each overexpressing a different peptide-1-A(b)(A(b)) complex. We show that a subset of CD4 T cells is selected by the overexpressed peptide and that the specificities of the CD4 T cells, as measured by reactivity to wild-type antigen-presenting cells, vary greatly depending on which peptide is overexpressed. These differences in specificity are mediated through positive selection not negative selection. Each of the four peptide-A(b) complexes appears to adopt a different conformation, and these differences correlate with the differences in reactivity. Our results suggest that individual peptide-MHC complexes positively select different subsets of self-MHC-reactive T cells and that the conformation of the peptide-MHC complex may contribute to this process.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-10023773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-10485652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-10607751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-11160293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-7484464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-8598039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-8598040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-8598041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-8638109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-8779719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9099796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9099801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9133419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9256469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9285402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9285404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9285405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9285406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9354472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9432982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9607927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9707606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9723702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9730891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12011451-9872742
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD22,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/CD22 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cd22 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/invariant chain,
http://linkedlifedata.com/resource/pubmed/chemical/rab5 GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6937-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12011451-Amino Acid Sequence,
pubmed-meshheading:12011451-Animals,
pubmed-meshheading:12011451-Antigen Presentation,
pubmed-meshheading:12011451-Antigens, CD,
pubmed-meshheading:12011451-Antigens, CD22,
pubmed-meshheading:12011451-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:12011451-Autoantigens,
pubmed-meshheading:12011451-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12011451-Cell Adhesion Molecules,
pubmed-meshheading:12011451-Histocompatibility Antigens Class II,
pubmed-meshheading:12011451-Humans,
pubmed-meshheading:12011451-Lectins,
pubmed-meshheading:12011451-Mice,
pubmed-meshheading:12011451-Mice, Inbred BALB C,
pubmed-meshheading:12011451-Mice, Inbred C57BL,
pubmed-meshheading:12011451-Mice, Transgenic,
pubmed-meshheading:12011451-Molecular Sequence Data,
pubmed-meshheading:12011451-Peptides,
pubmed-meshheading:12011451-rab5 GTP-Binding Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes.
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pubmed:affiliation |
Molecular and Cellular Biology Program, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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