Source:http://linkedlifedata.com/resource/pubmed/id/12010826
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0013018,
umls-concept:C0019721,
umls-concept:C0019728,
umls-concept:C0019737,
umls-concept:C0019764,
umls-concept:C0030705,
umls-concept:C0237519,
umls-concept:C0332835,
umls-concept:C0376152,
umls-concept:C0445356,
umls-concept:C1333899,
umls-concept:C1415561,
umls-concept:C1527169,
umls-concept:C1708943,
umls-concept:C2826293
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| pubmed:issue |
11
|
| pubmed:dateCreated |
2002-5-15
|
| pubmed:abstractText |
To improve the clinical outcome of allogeneic hematopoietic stem cell transplantation from an unrelated donor, the identification of human leukocyte antigen (HLA) alleles responsible for immunologic events such as graft-versus-host disease (GVHD), engraftment failure, and graft-versus-leukemia effect is essential. Genomic typing of HLA-A, -B, -C, -DRB1, and -DQB1 was retrospectively performed in 1298 donor-patient pairs in cases where marrow was donated from serologically HLA-A, -B, and -DR compatible donors. Single disparities of the HLA-A, -B, -C, or -DRB1 allele were independent risk factors for acute GVHD, and the synergistic effect of the HLA-C allele mismatch with other HLA allele mismatches on acute GVHD was remarkable. HLA-A and/or HLA-B allele mismatch was found to be a significant factor for the occurrence of chronic GVHD. HLA class I (A, B, and/or C) allele mismatch caused a significantly higher incidence of engraftment failure than HLA match. Significant association of HLA-C allele mismatch with leukemia relapse was not observed. As the result of these events, HLA-A and/or HLA-B allele mismatch reduced overall survival remarkably in both standard-risk and high-risk leukemia cases, whereas the HLA-C mismatch or HLA-class II (DRB1 and/or DQB1) mismatch did not. Furthermore, multiple mismatch of the HLA locus was found to reduce survival in leukemia cases. Thus, the role of the HLA class I allele in unrelated bone marrow transplantation was elucidated. Notably, HLA-C alleles had a different mode from HLA-A or -B alleles for acute GVHD and survival.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0006-4971
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| pubmed:author |
pubmed-author:AkazaTatsuyaT,
pubmed-author:AsanoShigetakaS,
pubmed-author:HamajimaNobuyukiN,
pubmed-author:InokoHidetoshiH,
pubmed-author:IshikawaYoshihideY,
pubmed-author:JujiTakeoT,
pubmed-author:KatoShunichiS,
pubmed-author:KawaKeiseiK,
pubmed-author:KoderaYoshihisaY,
pubmed-author:MorishimaYasuoY,
pubmed-author:SakamakiHisashiH,
pubmed-author:SaoHiroshiH,
pubmed-author:SasazukiTakehikoT,
pubmed-author:YamamotoKenK
|
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4200-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12010826-Adult,
pubmed-meshheading:12010826-Alleles,
pubmed-meshheading:12010826-Anemia, Aplastic,
pubmed-meshheading:12010826-Bone Marrow Transplantation,
pubmed-meshheading:12010826-Female,
pubmed-meshheading:12010826-Genetic Diseases, Inborn,
pubmed-meshheading:12010826-Graft vs Host Disease,
pubmed-meshheading:12010826-Graft vs Leukemia Effect,
pubmed-meshheading:12010826-HLA-A Antigens,
pubmed-meshheading:12010826-HLA-B Antigens,
pubmed-meshheading:12010826-HLA-DR Antigens,
pubmed-meshheading:12010826-Histocompatibility Testing,
pubmed-meshheading:12010826-Humans,
pubmed-meshheading:12010826-Immunosuppressive Agents,
pubmed-meshheading:12010826-Leukemia,
pubmed-meshheading:12010826-Lymphoma,
pubmed-meshheading:12010826-Male,
pubmed-meshheading:12010826-Myelodysplastic Syndromes,
pubmed-meshheading:12010826-Recurrence,
pubmed-meshheading:12010826-Retrospective Studies,
pubmed-meshheading:12010826-Tissue Donors,
pubmed-meshheading:12010826-Treatment Outcome
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors.
|
| pubmed:affiliation |
Department of Hematology and Chemotherapy, the Division of Epidemiology and Prevention, Aichi Cancer Center, Japan. ymorisim@aichi-cc.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|