Linked Life Data

12009791

Source:http://linkedlifedata.com/resource/pubmed/id/12009791

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2002-5-15
pubmed:abstractText
In this minireview, several different approaches to derivation of the theorems and relationships of Metabolic Control Analysis (MCA) are discussed and an alternative approach is presented. This new approach consists of solving the steady-state mass balances for the intracellular metabolites using linearized kinetics. The application of linearized kinetics reflects the fact that MCA is based on linearization of the system equations in a reference steady state. Our derivation is valid for metabolic networks of arbitrary complexity, including those containing conserved moieties and branches. The value of our approach is its simplicity: the derivation is straightforward and therefore easy to follow. It can serve as a compact introduction to the mathematical basis of MCA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1096-7176
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
114-23
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The mathematics of metabolic control analysis revisited.
pubmed:affiliation
Kluyverlaboratory for Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands.
pubmed:publicationType
Journal Article, Review