Source:http://linkedlifedata.com/resource/pubmed/id/12009056
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-5-14
|
| pubmed:abstractText |
Rainbow trout (Oncorhynchus mykiss) were bath challenged with viral hemorrhagic septicemia (VHS) virus or infectious hematopoietic necrosis (IHN) virus or with both viruses simultaneously. The viral distribution and development of histologic lesions were examined using immunohistochemistry, while virus titer in kidney was determined by viral titration in cell culture. Single infections with VHS virus and IHN virus showed similar distributions of virus in internal organs. The early identification of virus in gill epithelium, 1 and 2 days postinfection (PI) for VHS virus and IHN virus, respectively, indicates that this organ is the point of entry for both viruses. The detection of VHS virus at 1 day PI and 3 days PI for IHN virus is indicative of kidney and spleen being the target organs for these viruses. A simultaneous infection of VHS virus and IHN virus resulted in both viruses establishing an infection. Further double infection did not result in a statistically significant lower titer of both viruses in kidney but a more restricted distribution of IHN virus in internal organs compared with the single infected group. The most striking finding is that, for IHN virus, virus was not detected in the brain in situ in the double-infected group. This study provides support for the conclusion that simultaneous infection with two piscine rhabdoviruses in a susceptible host results in some degree of interaction at the cell level, leading to a reduced systemic distribution of IHN virus.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0300-9858
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
180-9
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12009056-Animals,
pubmed-meshheading:12009056-Fish Diseases,
pubmed-meshheading:12009056-Gills,
pubmed-meshheading:12009056-Hemorrhagic Septicemia, Viral,
pubmed-meshheading:12009056-Immunohistochemistry,
pubmed-meshheading:12009056-Infectious hematopoietic necrosis virus,
pubmed-meshheading:12009056-Kidney,
pubmed-meshheading:12009056-Novirhabdovirus,
pubmed-meshheading:12009056-Oncorhynchus mykiss,
pubmed-meshheading:12009056-Organ Specificity,
pubmed-meshheading:12009056-Rhabdoviridae Infections,
pubmed-meshheading:12009056-Spleen,
pubmed-meshheading:12009056-Virus Replication
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Studies on pathogenesis following single and double infection with viral hemorrhagic septicemia virus and infectious hematopoietic necrosis virus in rainbow trout (Oncorhynchus mykiss).
|
| pubmed:affiliation |
National Veterinary Institute, Department of Pathology, Olso, Norway.
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| pubmed:publicationType |
Journal Article
|